Occurrence of CA 125 and CA 19-9 tumor-associated antigens in sera of patients with gynecologic, trophoblastic, and colorectal tumors

P. M. Göcze, D. G. Szabó, G. N. Than, Imre F. Csaha, K. F. Krommer

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The present study was undertaken to test the parallel detectability of ovarian cancer antigen CA 125 and gastrointestinal cancer antigen CA 19-9 in the sera of patients with malignant ovarian tumors, benign ovarian tumors, endometrial cancers, cervical cancers, colorectal cancers, and trophoblastic tumors and in early lst-trimester pregnant as well as in healthy nonpregnant controls. In all kinds of gynecologic and colorectal tumors raised concentrations of both antigens were found with the exception of malignant nonepithclial ovarian tumors where neither of the antigens showed positive reaction. The most positive cases were found in the group with epithelial ovarian cancers. Of the two antigens CA 125 was the more responsive. No positive cases were found with either of the antigens in nonpregnant healthy controls or in patients with benign ovarian tumors. The parallel determination of the two antigens gives us a better opportunity to recognize pelvic tumors and further may enable us to distinguish ovarian and colorectal tumors.

Original languageEnglish
Pages (from-to)268-272
Number of pages5
JournalGynecologic and Obstetric Investigation
Volume25
Issue number4
DOIs
Publication statusPublished - Jan 1 1988

Keywords

  • CA 125, ovarian cancer antigen
  • CA 19-9, gastrointestinal cancer antigen
  • Tumors

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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