Occurrence of anti-low density lipoprotein antibodies and circulating immune complexes in aged subjects

Éva Szondy, Éva Lengyel, Zsuzsa Mezey, G. Füst, Sándor Gerö

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The incidence of circulating immune complexes, anti-low density lipoprotein (LDL) autoantibodies and the anti-LDL activity of immune complexes was studied in healthy young and aged controls and in patients with vascular diseases. Circulating immune complexes (CIC) frequently occurred both in the young or old patient groups and in the aged healthy control groups, whereas they could not be found in the young controls. Marked differences were found in the incidence of anti-LDL antibodies between the groups tested. In both young and aged control groups such antibodies were very rarely observed (4-5%). In contrast anti-LDL antibodies were present in 35-45% in the aged, or young patients. Similarly, no anti-LDL activity was found in CIC of the controls, whereas in the patients with vascular diseases a significant CIC-associated anti-LDL activity was detected. These results suggest that the presence of anti-LDL antibodies are associated with the arteriosclerotic manifestations, while that of circulating immune complexes is connected by the ageing process itself.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalMechanisms of Ageing and Development
Volume29
Issue number2
DOIs
Publication statusPublished - 1985

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Antigen-Antibody Complex
LDL Lipoproteins
Antibodies
Vascular Diseases
Control Groups
Incidence
Autoantibodies
Aging of materials

Keywords

  • Ageing
  • Antibodies
  • Arteriosclerosis
  • Circulating immune complexes

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Occurrence of anti-low density lipoprotein antibodies and circulating immune complexes in aged subjects. / Szondy, Éva; Lengyel, Éva; Mezey, Zsuzsa; Füst, G.; Gerö, Sándor.

In: Mechanisms of Ageing and Development, Vol. 29, No. 2, 1985, p. 117-123.

Research output: Contribution to journalArticle

Szondy, Éva ; Lengyel, Éva ; Mezey, Zsuzsa ; Füst, G. ; Gerö, Sándor. / Occurrence of anti-low density lipoprotein antibodies and circulating immune complexes in aged subjects. In: Mechanisms of Ageing and Development. 1985 ; Vol. 29, No. 2. pp. 117-123.
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