Occupational prestige, social mobility and the association with lung cancer in men

Thomas Behrens, Isabelle Groß, Jack Siemiatycki, David I. Conway, Ann Olsson, Isabelle Stücker, Florence Guida, Karl Heinz Jöckel, Hermann Pohlabeln, Wolfgang Ahrens, Irene Brüske, Heinz Erich Wichmann, Per Gustavsson, Dario Consonni, Franco Merletti, Lorenzo Richiardi, Lorenzo Simonato, Cristina Fortes, Marie Elise Parent, John McLaughlin & 23 others Paul Demers, Maria Teresa Landi, Neil Caporaso, David Zaridze, Neonila Szeszenia-Dabrowska, P. Rudnai, Jolanta Lissowska, Eleonora Fabianova, Adonina Tardón, John K. Field, Rodica Stanescu Dumitru, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Hans Kromhout, Roel Vermeulen, Paolo Boffetta, Kurt Straif, Joachim Schüz, Jan Hovanec, Benjamin Kendzia, Beate Pesch, Thomas Brüning

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: The nature of the association between occupational social prestige, social mobility, and risk of lung cancer remains uncertain. Using data from the international pooled SYNERGY case-control study, we studied the association between lung cancer and the level of time-weighted average occupational social prestige as well as its lifetime trajectory. Methods: We included 11,433 male cases and 14,147 male control subjects. Each job was translated into an occupational social prestige score by applying Treiman's Standard International Occupational Prestige Scale (SIOPS). SIOPS scores were categorized as low, medium, and high prestige (reference). We calculated odds ratios (OR) with 95 % confidence intervals (CI), adjusting for study center, age, smoking, ever employment in a job with known lung carcinogen exposure, and education. Trajectories in SIOPS categories from first to last and first to longest job were defined as consistent, downward, or upward. We conducted several subgroup and sensitivity analyses to assess the robustness of our results. Results: We observed increased lung cancer risk estimates for men with medium (OR = 1.23; 95 % CI 1.13-1.33) and low occupational prestige (OR = 1.44; 95 % CI 1.32-1.57). Although adjustment for smoking and education reduced the associations between occupational prestige and lung cancer, they did not explain the association entirely. Traditional occupational exposures reduced the associations only slightly. We observed small associations with downward prestige trajectories, with ORs of 1.13, 95 % CI 0.88-1.46 for high to low, and 1.24; 95 % CI 1.08-1.41 for medium to low trajectories. Conclusions: Our results indicate that occupational prestige is independently associated with lung cancer among men.

Original languageEnglish
Article number395
JournalBMC Cancer
Volume16
Issue number1
DOIs
Publication statusPublished - Jul 7 2016

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Social Mobility
Lung Neoplasms
Confidence Intervals
Odds Ratio
Smoking
Education
Occupational Exposure
Carcinogens
Case-Control Studies
Lung

Keywords

  • Life course
  • Occupational history
  • Social prestige
  • Socio-economic status
  • SYNERGY
  • Transitions

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

Cite this

Behrens, T., Groß, I., Siemiatycki, J., Conway, D. I., Olsson, A., Stücker, I., ... Brüning, T. (2016). Occupational prestige, social mobility and the association with lung cancer in men. BMC Cancer, 16(1), [395]. https://doi.org/10.1186/s12885-016-2432-9

Occupational prestige, social mobility and the association with lung cancer in men. / Behrens, Thomas; Groß, Isabelle; Siemiatycki, Jack; Conway, David I.; Olsson, Ann; Stücker, Isabelle; Guida, Florence; Jöckel, Karl Heinz; Pohlabeln, Hermann; Ahrens, Wolfgang; Brüske, Irene; Wichmann, Heinz Erich; Gustavsson, Per; Consonni, Dario; Merletti, Franco; Richiardi, Lorenzo; Simonato, Lorenzo; Fortes, Cristina; Parent, Marie Elise; McLaughlin, John; Demers, Paul; Landi, Maria Teresa; Caporaso, Neil; Zaridze, David; Szeszenia-Dabrowska, Neonila; Rudnai, P.; Lissowska, Jolanta; Fabianova, Eleonora; Tardón, Adonina; Field, John K.; Dumitru, Rodica Stanescu; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Kromhout, Hans; Vermeulen, Roel; Boffetta, Paolo; Straif, Kurt; Schüz, Joachim; Hovanec, Jan; Kendzia, Benjamin; Pesch, Beate; Brüning, Thomas.

In: BMC Cancer, Vol. 16, No. 1, 395, 07.07.2016.

Research output: Contribution to journalArticle

Behrens, T, Groß, I, Siemiatycki, J, Conway, DI, Olsson, A, Stücker, I, Guida, F, Jöckel, KH, Pohlabeln, H, Ahrens, W, Brüske, I, Wichmann, HE, Gustavsson, P, Consonni, D, Merletti, F, Richiardi, L, Simonato, L, Fortes, C, Parent, ME, McLaughlin, J, Demers, P, Landi, MT, Caporaso, N, Zaridze, D, Szeszenia-Dabrowska, N, Rudnai, P, Lissowska, J, Fabianova, E, Tardón, A, Field, JK, Dumitru, RS, Bencko, V, Foretova, L, Janout, V, Kromhout, H, Vermeulen, R, Boffetta, P, Straif, K, Schüz, J, Hovanec, J, Kendzia, B, Pesch, B & Brüning, T 2016, 'Occupational prestige, social mobility and the association with lung cancer in men', BMC Cancer, vol. 16, no. 1, 395. https://doi.org/10.1186/s12885-016-2432-9
Behrens T, Groß I, Siemiatycki J, Conway DI, Olsson A, Stücker I et al. Occupational prestige, social mobility and the association with lung cancer in men. BMC Cancer. 2016 Jul 7;16(1). 395. https://doi.org/10.1186/s12885-016-2432-9
Behrens, Thomas ; Groß, Isabelle ; Siemiatycki, Jack ; Conway, David I. ; Olsson, Ann ; Stücker, Isabelle ; Guida, Florence ; Jöckel, Karl Heinz ; Pohlabeln, Hermann ; Ahrens, Wolfgang ; Brüske, Irene ; Wichmann, Heinz Erich ; Gustavsson, Per ; Consonni, Dario ; Merletti, Franco ; Richiardi, Lorenzo ; Simonato, Lorenzo ; Fortes, Cristina ; Parent, Marie Elise ; McLaughlin, John ; Demers, Paul ; Landi, Maria Teresa ; Caporaso, Neil ; Zaridze, David ; Szeszenia-Dabrowska, Neonila ; Rudnai, P. ; Lissowska, Jolanta ; Fabianova, Eleonora ; Tardón, Adonina ; Field, John K. ; Dumitru, Rodica Stanescu ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; Kromhout, Hans ; Vermeulen, Roel ; Boffetta, Paolo ; Straif, Kurt ; Schüz, Joachim ; Hovanec, Jan ; Kendzia, Benjamin ; Pesch, Beate ; Brüning, Thomas. / Occupational prestige, social mobility and the association with lung cancer in men. In: BMC Cancer. 2016 ; Vol. 16, No. 1.
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abstract = "Background: The nature of the association between occupational social prestige, social mobility, and risk of lung cancer remains uncertain. Using data from the international pooled SYNERGY case-control study, we studied the association between lung cancer and the level of time-weighted average occupational social prestige as well as its lifetime trajectory. Methods: We included 11,433 male cases and 14,147 male control subjects. Each job was translated into an occupational social prestige score by applying Treiman's Standard International Occupational Prestige Scale (SIOPS). SIOPS scores were categorized as low, medium, and high prestige (reference). We calculated odds ratios (OR) with 95 {\%} confidence intervals (CI), adjusting for study center, age, smoking, ever employment in a job with known lung carcinogen exposure, and education. Trajectories in SIOPS categories from first to last and first to longest job were defined as consistent, downward, or upward. We conducted several subgroup and sensitivity analyses to assess the robustness of our results. Results: We observed increased lung cancer risk estimates for men with medium (OR = 1.23; 95 {\%} CI 1.13-1.33) and low occupational prestige (OR = 1.44; 95 {\%} CI 1.32-1.57). Although adjustment for smoking and education reduced the associations between occupational prestige and lung cancer, they did not explain the association entirely. Traditional occupational exposures reduced the associations only slightly. We observed small associations with downward prestige trajectories, with ORs of 1.13, 95 {\%} CI 0.88-1.46 for high to low, and 1.24; 95 {\%} CI 1.08-1.41 for medium to low trajectories. Conclusions: Our results indicate that occupational prestige is independently associated with lung cancer among men.",
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AU - Behrens, Thomas

AU - Groß, Isabelle

AU - Siemiatycki, Jack

AU - Conway, David I.

AU - Olsson, Ann

AU - Stücker, Isabelle

AU - Guida, Florence

AU - Jöckel, Karl Heinz

AU - Pohlabeln, Hermann

AU - Ahrens, Wolfgang

AU - Brüske, Irene

AU - Wichmann, Heinz Erich

AU - Gustavsson, Per

AU - Consonni, Dario

AU - Merletti, Franco

AU - Richiardi, Lorenzo

AU - Simonato, Lorenzo

AU - Fortes, Cristina

AU - Parent, Marie Elise

AU - McLaughlin, John

AU - Demers, Paul

AU - Landi, Maria Teresa

AU - Caporaso, Neil

AU - Zaridze, David

AU - Szeszenia-Dabrowska, Neonila

AU - Rudnai, P.

AU - Lissowska, Jolanta

AU - Fabianova, Eleonora

AU - Tardón, Adonina

AU - Field, John K.

AU - Dumitru, Rodica Stanescu

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Kromhout, Hans

AU - Vermeulen, Roel

AU - Boffetta, Paolo

AU - Straif, Kurt

AU - Schüz, Joachim

AU - Hovanec, Jan

AU - Kendzia, Benjamin

AU - Pesch, Beate

AU - Brüning, Thomas

PY - 2016/7/7

Y1 - 2016/7/7

N2 - Background: The nature of the association between occupational social prestige, social mobility, and risk of lung cancer remains uncertain. Using data from the international pooled SYNERGY case-control study, we studied the association between lung cancer and the level of time-weighted average occupational social prestige as well as its lifetime trajectory. Methods: We included 11,433 male cases and 14,147 male control subjects. Each job was translated into an occupational social prestige score by applying Treiman's Standard International Occupational Prestige Scale (SIOPS). SIOPS scores were categorized as low, medium, and high prestige (reference). We calculated odds ratios (OR) with 95 % confidence intervals (CI), adjusting for study center, age, smoking, ever employment in a job with known lung carcinogen exposure, and education. Trajectories in SIOPS categories from first to last and first to longest job were defined as consistent, downward, or upward. We conducted several subgroup and sensitivity analyses to assess the robustness of our results. Results: We observed increased lung cancer risk estimates for men with medium (OR = 1.23; 95 % CI 1.13-1.33) and low occupational prestige (OR = 1.44; 95 % CI 1.32-1.57). Although adjustment for smoking and education reduced the associations between occupational prestige and lung cancer, they did not explain the association entirely. Traditional occupational exposures reduced the associations only slightly. We observed small associations with downward prestige trajectories, with ORs of 1.13, 95 % CI 0.88-1.46 for high to low, and 1.24; 95 % CI 1.08-1.41 for medium to low trajectories. Conclusions: Our results indicate that occupational prestige is independently associated with lung cancer among men.

AB - Background: The nature of the association between occupational social prestige, social mobility, and risk of lung cancer remains uncertain. Using data from the international pooled SYNERGY case-control study, we studied the association between lung cancer and the level of time-weighted average occupational social prestige as well as its lifetime trajectory. Methods: We included 11,433 male cases and 14,147 male control subjects. Each job was translated into an occupational social prestige score by applying Treiman's Standard International Occupational Prestige Scale (SIOPS). SIOPS scores were categorized as low, medium, and high prestige (reference). We calculated odds ratios (OR) with 95 % confidence intervals (CI), adjusting for study center, age, smoking, ever employment in a job with known lung carcinogen exposure, and education. Trajectories in SIOPS categories from first to last and first to longest job were defined as consistent, downward, or upward. We conducted several subgroup and sensitivity analyses to assess the robustness of our results. Results: We observed increased lung cancer risk estimates for men with medium (OR = 1.23; 95 % CI 1.13-1.33) and low occupational prestige (OR = 1.44; 95 % CI 1.32-1.57). Although adjustment for smoking and education reduced the associations between occupational prestige and lung cancer, they did not explain the association entirely. Traditional occupational exposures reduced the associations only slightly. We observed small associations with downward prestige trajectories, with ORs of 1.13, 95 % CI 0.88-1.46 for high to low, and 1.24; 95 % CI 1.08-1.41 for medium to low trajectories. Conclusions: Our results indicate that occupational prestige is independently associated with lung cancer among men.

KW - Life course

KW - Occupational history

KW - Social prestige

KW - Socio-economic status

KW - SYNERGY

KW - Transitions

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