Occupational exposure to polycyclic aromatic hydrocarbons and lung cancer risk: A multicenter study in Europe

Ann C. Olsson, Joelle Fevotte, Tony Fletcher, Adrian Cassidy, Andrea 'T Mannetje, David Zaridze, Neonila Szeszenia-Dabrowska, P. Rudnai, Jolanta Lissowska, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Paul Brennan, Paolo Boffetta

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Abstract

Background: Lung cancer incidence in Central and Eastern Europe (CEE) is among the highest in the world, and the role of occupational exposures has not been adequately studied in these countries. Objectives: To investigate the contribution of occupational exposure to polycyclic aromatic hydrocarbons (PAH) to lung cancer in CEE. Methods: A caseecontrol study was conducted in the Czech Republic, Hungary, Poland, Romania, Russia and Slovakia, as well as the United Kingdom (UK) between 1998 and 2002. Occupational and socio-demographic information was collected through interviews from 2861 newly diagnosed lung cancer cases and 2936 population or hospital controls. Industrial hygiene experts in each country evaluated exposure to 70 occupational agents, whereof 15 mixtures containing PAH. ORs of lung cancer were calculated after adjusting for other occupational exposures and tobacco smoking. Results: The OR for ever exposure to PAH in the CEE countries was 0.93 (95% CI 0.77 to 1.14). The ORs for the highest category of cumulative exposure, duration of exposure and intensity of exposure were 1.13 (95% CI 0.80 to 1.58), 1.02 (95% CI 0.66 to 1.57) and 1.11 (95% CI 0.60 to 2.05), respectively. The OR for ever PAH exposure in the UK was 1.97 (95% CI 1.16 to 3.35). Conclusion: Occupational PAH exposure does not appear to substantially contribute to the burden of lung cancer in CEE. The apparently stronger effect observed in the UK may be due to high exposure levels and a joint effect with asbestos.

Original languageEnglish
Pages (from-to)98-103
Number of pages6
JournalOccupational and Environmental Medicine
Volume67
Issue number2
DOIs
Publication statusPublished - Feb 1 2010

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Polycyclic Aromatic Hydrocarbons
Occupational Exposure
Eastern Europe
Multicenter Studies
Lung Neoplasms
Romania
Slovakia
Hungary
Czech Republic
Asbestos
Russia
Occupational Health
Poland
Smoking
Demography
Interviews
Incidence
Population
United Kingdom

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Olsson, A. C., Fevotte, J., Fletcher, T., Cassidy, A., 'T Mannetje, A., Zaridze, D., ... Boffetta, P. (2010). Occupational exposure to polycyclic aromatic hydrocarbons and lung cancer risk: A multicenter study in Europe. Occupational and Environmental Medicine, 67(2), 98-103. https://doi.org/10.1136/oem.2009.046680

Occupational exposure to polycyclic aromatic hydrocarbons and lung cancer risk : A multicenter study in Europe. / Olsson, Ann C.; Fevotte, Joelle; Fletcher, Tony; Cassidy, Adrian; 'T Mannetje, Andrea; Zaridze, David; Szeszenia-Dabrowska, Neonila; Rudnai, P.; Lissowska, Jolanta; Fabianova, Eleonora; Mates, Dana; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Brennan, Paul; Boffetta, Paolo.

In: Occupational and Environmental Medicine, Vol. 67, No. 2, 01.02.2010, p. 98-103.

Research output: Contribution to journalArticle

Olsson, AC, Fevotte, J, Fletcher, T, Cassidy, A, 'T Mannetje, A, Zaridze, D, Szeszenia-Dabrowska, N, Rudnai, P, Lissowska, J, Fabianova, E, Mates, D, Bencko, V, Foretova, L, Janout, V, Brennan, P & Boffetta, P 2010, 'Occupational exposure to polycyclic aromatic hydrocarbons and lung cancer risk: A multicenter study in Europe', Occupational and Environmental Medicine, vol. 67, no. 2, pp. 98-103. https://doi.org/10.1136/oem.2009.046680
Olsson, Ann C. ; Fevotte, Joelle ; Fletcher, Tony ; Cassidy, Adrian ; 'T Mannetje, Andrea ; Zaridze, David ; Szeszenia-Dabrowska, Neonila ; Rudnai, P. ; Lissowska, Jolanta ; Fabianova, Eleonora ; Mates, Dana ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; Brennan, Paul ; Boffetta, Paolo. / Occupational exposure to polycyclic aromatic hydrocarbons and lung cancer risk : A multicenter study in Europe. In: Occupational and Environmental Medicine. 2010 ; Vol. 67, No. 2. pp. 98-103.
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abstract = "Background: Lung cancer incidence in Central and Eastern Europe (CEE) is among the highest in the world, and the role of occupational exposures has not been adequately studied in these countries. Objectives: To investigate the contribution of occupational exposure to polycyclic aromatic hydrocarbons (PAH) to lung cancer in CEE. Methods: A caseecontrol study was conducted in the Czech Republic, Hungary, Poland, Romania, Russia and Slovakia, as well as the United Kingdom (UK) between 1998 and 2002. Occupational and socio-demographic information was collected through interviews from 2861 newly diagnosed lung cancer cases and 2936 population or hospital controls. Industrial hygiene experts in each country evaluated exposure to 70 occupational agents, whereof 15 mixtures containing PAH. ORs of lung cancer were calculated after adjusting for other occupational exposures and tobacco smoking. Results: The OR for ever exposure to PAH in the CEE countries was 0.93 (95{\%} CI 0.77 to 1.14). The ORs for the highest category of cumulative exposure, duration of exposure and intensity of exposure were 1.13 (95{\%} CI 0.80 to 1.58), 1.02 (95{\%} CI 0.66 to 1.57) and 1.11 (95{\%} CI 0.60 to 2.05), respectively. The OR for ever PAH exposure in the UK was 1.97 (95{\%} CI 1.16 to 3.35). Conclusion: Occupational PAH exposure does not appear to substantially contribute to the burden of lung cancer in CEE. The apparently stronger effect observed in the UK may be due to high exposure levels and a joint effect with asbestos.",
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AU - 'T Mannetje, Andrea

AU - Zaridze, David

AU - Szeszenia-Dabrowska, Neonila

AU - Rudnai, P.

AU - Lissowska, Jolanta

AU - Fabianova, Eleonora

AU - Mates, Dana

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Brennan, Paul

AU - Boffetta, Paolo

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N2 - Background: Lung cancer incidence in Central and Eastern Europe (CEE) is among the highest in the world, and the role of occupational exposures has not been adequately studied in these countries. Objectives: To investigate the contribution of occupational exposure to polycyclic aromatic hydrocarbons (PAH) to lung cancer in CEE. Methods: A caseecontrol study was conducted in the Czech Republic, Hungary, Poland, Romania, Russia and Slovakia, as well as the United Kingdom (UK) between 1998 and 2002. Occupational and socio-demographic information was collected through interviews from 2861 newly diagnosed lung cancer cases and 2936 population or hospital controls. Industrial hygiene experts in each country evaluated exposure to 70 occupational agents, whereof 15 mixtures containing PAH. ORs of lung cancer were calculated after adjusting for other occupational exposures and tobacco smoking. Results: The OR for ever exposure to PAH in the CEE countries was 0.93 (95% CI 0.77 to 1.14). The ORs for the highest category of cumulative exposure, duration of exposure and intensity of exposure were 1.13 (95% CI 0.80 to 1.58), 1.02 (95% CI 0.66 to 1.57) and 1.11 (95% CI 0.60 to 2.05), respectively. The OR for ever PAH exposure in the UK was 1.97 (95% CI 1.16 to 3.35). Conclusion: Occupational PAH exposure does not appear to substantially contribute to the burden of lung cancer in CEE. The apparently stronger effect observed in the UK may be due to high exposure levels and a joint effect with asbestos.

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