Abstract
BACKGROUND: The role of crystalline silica dust as a possible cause of lung cancer has been controversial. Relatively few large community-based studies have been conducted to investigate the lung cancer risk from exposure to silica at low levels, taking into account potential confounding factors. METHODS: Detailed lifestyle and occupational information were collected from 2852 newly diagnosed cases of lung cancer and 3104 controls between 1998 and 2002 in 7 European countries. For each job held, local experts assessed the probability, intensity, and duration of silica exposure. RESULTS: Occupational exposure to crystalline silica was associated with an increased risk of lung cancer (odds ratio = 1.37; 95% confidence interval = 1.14-1.65). This risk was most apparent for the upper tertile of cumulative exposure (OR = 2.08; 95% CI = 1.49-2.90; P for trend
| Original language | English |
|---|---|
| Pages (from-to) | 36-43 |
| Number of pages | 8 |
| Journal | Epidemiology |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2007 |
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ASJC Scopus subject areas
- Epidemiology
Cite this
Occupational exposure to crystalline silica and risk of lung cancer : A multicenter case-control study in Europe. / Cassidy, Adrian; Mannetje, Andrea't; Van Tongeren, Martie; Field, John K.; Zaridze, David; Szeszenia-Dabrowska, Neonila; Rudnai, P.; Lissowska, Jolanta; Fabianova, Eleonora; Mates, Dana; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Fevotte, Joelle; Fletcher, Tony; Brennan, Paul; Boffetta, Paolo.
In: Epidemiology, Vol. 18, No. 1, 01.2007, p. 36-43.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Occupational exposure to crystalline silica and risk of lung cancer
T2 - A multicenter case-control study in Europe
AU - Cassidy, Adrian
AU - Mannetje, Andrea't
AU - Van Tongeren, Martie
AU - Field, John K.
AU - Zaridze, David
AU - Szeszenia-Dabrowska, Neonila
AU - Rudnai, P.
AU - Lissowska, Jolanta
AU - Fabianova, Eleonora
AU - Mates, Dana
AU - Bencko, Vladimir
AU - Foretova, Lenka
AU - Janout, Vladimir
AU - Fevotte, Joelle
AU - Fletcher, Tony
AU - Brennan, Paul
AU - Boffetta, Paolo
PY - 2007/1
Y1 - 2007/1
N2 - BACKGROUND: The role of crystalline silica dust as a possible cause of lung cancer has been controversial. Relatively few large community-based studies have been conducted to investigate the lung cancer risk from exposure to silica at low levels, taking into account potential confounding factors. METHODS: Detailed lifestyle and occupational information were collected from 2852 newly diagnosed cases of lung cancer and 3104 controls between 1998 and 2002 in 7 European countries. For each job held, local experts assessed the probability, intensity, and duration of silica exposure. RESULTS: Occupational exposure to crystalline silica was associated with an increased risk of lung cancer (odds ratio = 1.37; 95% confidence interval = 1.14-1.65). This risk was most apparent for the upper tertile of cumulative exposure (OR = 2.08; 95% CI = 1.49-2.90; P for trend
AB - BACKGROUND: The role of crystalline silica dust as a possible cause of lung cancer has been controversial. Relatively few large community-based studies have been conducted to investigate the lung cancer risk from exposure to silica at low levels, taking into account potential confounding factors. METHODS: Detailed lifestyle and occupational information were collected from 2852 newly diagnosed cases of lung cancer and 3104 controls between 1998 and 2002 in 7 European countries. For each job held, local experts assessed the probability, intensity, and duration of silica exposure. RESULTS: Occupational exposure to crystalline silica was associated with an increased risk of lung cancer (odds ratio = 1.37; 95% confidence interval = 1.14-1.65). This risk was most apparent for the upper tertile of cumulative exposure (OR = 2.08; 95% CI = 1.49-2.90; P for trend
UR - http://www.scopus.com/inward/record.url?scp=33845802494&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845802494&partnerID=8YFLogxK
U2 - 10.1097/01.ede.0000248515.28903.3c
DO - 10.1097/01.ede.0000248515.28903.3c
M3 - Article
C2 - 17149143
AN - SCOPUS:33845802494
VL - 18
SP - 36
EP - 43
JO - Epidemiology
JF - Epidemiology
SN - 1044-3983
IS - 1
ER -