Occupational exposure to crystalline silica and risk of lung cancer: A multicenter case-control study in Europe

Adrian Cassidy, Andrea't Mannetje, Martie Van Tongeren, John K. Field, David Zaridze, Neonila Szeszenia-Dabrowska, P. Rudnai, Jolanta Lissowska, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Joelle Fevotte, Tony Fletcher, Paul Brennan, Paolo Boffetta

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Abstract

BACKGROUND: The role of crystalline silica dust as a possible cause of lung cancer has been controversial. Relatively few large community-based studies have been conducted to investigate the lung cancer risk from exposure to silica at low levels, taking into account potential confounding factors. METHODS: Detailed lifestyle and occupational information were collected from 2852 newly diagnosed cases of lung cancer and 3104 controls between 1998 and 2002 in 7 European countries. For each job held, local experts assessed the probability, intensity, and duration of silica exposure. RESULTS: Occupational exposure to crystalline silica was associated with an increased risk of lung cancer (odds ratio = 1.37; 95% confidence interval = 1.14-1.65). This risk was most apparent for the upper tertile of cumulative exposure (OR = 2.08; 95% CI = 1.49-2.90; P for trend

Original languageEnglish
Pages (from-to)36-43
Number of pages8
JournalEpidemiology
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2007

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Occupational Exposure
Silicon Dioxide
Case-Control Studies
Lung Neoplasms
Dust
Life Style
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Epidemiology

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Cassidy, A., Mannetje, A., Van Tongeren, M., Field, J. K., Zaridze, D., Szeszenia-Dabrowska, N., ... Boffetta, P. (2007). Occupational exposure to crystalline silica and risk of lung cancer: A multicenter case-control study in Europe. Epidemiology, 18(1), 36-43. https://doi.org/10.1097/01.ede.0000248515.28903.3c

Occupational exposure to crystalline silica and risk of lung cancer : A multicenter case-control study in Europe. / Cassidy, Adrian; Mannetje, Andrea't; Van Tongeren, Martie; Field, John K.; Zaridze, David; Szeszenia-Dabrowska, Neonila; Rudnai, P.; Lissowska, Jolanta; Fabianova, Eleonora; Mates, Dana; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Fevotte, Joelle; Fletcher, Tony; Brennan, Paul; Boffetta, Paolo.

In: Epidemiology, Vol. 18, No. 1, 01.2007, p. 36-43.

Research output: Contribution to journalArticle

Cassidy, A, Mannetje, A, Van Tongeren, M, Field, JK, Zaridze, D, Szeszenia-Dabrowska, N, Rudnai, P, Lissowska, J, Fabianova, E, Mates, D, Bencko, V, Foretova, L, Janout, V, Fevotte, J, Fletcher, T, Brennan, P & Boffetta, P 2007, 'Occupational exposure to crystalline silica and risk of lung cancer: A multicenter case-control study in Europe', Epidemiology, vol. 18, no. 1, pp. 36-43. https://doi.org/10.1097/01.ede.0000248515.28903.3c
Cassidy, Adrian ; Mannetje, Andrea't ; Van Tongeren, Martie ; Field, John K. ; Zaridze, David ; Szeszenia-Dabrowska, Neonila ; Rudnai, P. ; Lissowska, Jolanta ; Fabianova, Eleonora ; Mates, Dana ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; Fevotte, Joelle ; Fletcher, Tony ; Brennan, Paul ; Boffetta, Paolo. / Occupational exposure to crystalline silica and risk of lung cancer : A multicenter case-control study in Europe. In: Epidemiology. 2007 ; Vol. 18, No. 1. pp. 36-43.
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