Occupational epidemiological study of workers in an acrylonitrile using factory with particular attention to cancers and birth defects

E. Czeizel, Réka Szilvási, László Tímár, E. Puhó

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

An occupational epidemiological study was organised among workers in an acrylonitrile using factory in Hungary. Of the 888 workers, 783 were included in the study and three groups were differentiated: Group A (N=452) with direct and continuous exposure, Group B (N=171) with direct but occasional exposure and Group C (N=160) without direct exposure, as referent. There were two main objectives: to determine the occurrence of cancer in workers and congenital abnormalities in their liveborn infants. The study did not indicate a higher occurrence of cancer among workers: only one lung cancer patient was found, prostate cancer did not occur. Among congenital abnormalities, the group of specified multiple congenital abnormalities showed a higher rate than expected but characteristic defect-pattern was not found among seven multimalformed babies, though five had cardiovascular malformations. In conclusion, our study did not indicate the carcinogenic, mutagenic and teratogenic effect of acrylonitrile among workers using this chemical in the factory.

Original languageEnglish
Pages (from-to)79-89
Number of pages11
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume547
Issue number1-2
DOIs
Publication statusPublished - Mar 22 2004

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Acrylonitrile
Epidemiologic Studies
Multiple Abnormalities
Neoplasms
Hungary
Lung Neoplasms
Prostatic Neoplasms

Keywords

  • Acrylonitrile
  • Cancers
  • Congenital abnormalities
  • Occupational study

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Molecular Biology

Cite this

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AU - Czeizel, E.

AU - Szilvási, Réka

AU - Tímár, László

AU - Puhó, E.

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KW - Acrylonitrile

KW - Cancers

KW - Congenital abnormalities

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