Obstetric and neonatal risk of pregnancies after assisted reproductive technology: A matched control study

Zoltán Kozinsky, János Zádori, H. Orvos, M. Katona, A. Pál, László Kovács

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Background. The aim of the study was to evaluate the obstetric and neonatal outcome of pregnancies after assisted reproduction technology (ART) in comparison with matched controls from spontaneous pregnancies. Methods. A total of 12920 deliveries at the Department of Obstetrics and Gynecology, University of Szeged, from 1 January 1995 to 31 December 2001 were subjected to retrospective analysis. Two hundred and eighty-four singleton, 75 twin and 17 triplet pregnancies after ovulation induction (n = 114; 30.3%), intrauterine insemination (n = 33; 8.8%) and in vitro fertilization (n = 229; 60.9%) were evaluated. The pregnancy outcome of the singleton and twin pregnancies was compared with that for controls matched with regard to age, gravidity and parity and previous obstetric outcome after spontaneous pregnancies. Results. Twenty-four percent of the assisted reproductive pregnancies were multiple pregnancies. The incidences of singleton intrauterine growth retardation (IUGR) and preterm birth were reasonably similar to those among the controls (IUGR: 6.3% vs. 4.2%; preterm births: 13.0% vs. 9.9%, for the cases and the controls, respectively). As compared with the controls, there was an increased incidence of cesarean section among the singleton (41.2% vs. 34.5%, p = 0.12; OR 1.33; 95% CI 0.95-1.87) and twin assisted reproduction pregnancies (66.7% vs. 60.0%), but without significant differences. Conclusions. Increased obstetric risk could be observed concerning threatened preterm delivery and cesarean section rate in the study group. The perinatal outcome of singleton and twin pregnancies following assisted reproductive techniques is comparable with that of spontaneously conceived, matched pregnancies.

Original languageEnglish
Pages (from-to)850-856
Number of pages7
JournalActa Obstetricia et Gynecologica Scandinavica
Volume82
Issue number9
DOIs
Publication statusPublished - Sep 1 2003

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Assisted Reproductive Techniques
Obstetrics
Pregnancy
Twin Pregnancy
Fetal Growth Retardation
Premature Birth
Pregnancy Outcome
Cesarean Section
Reproduction
Triplet Pregnancy
Gravidity
Multiple Pregnancy
Hospital Obstetrics and Gynecology Department
Ovulation Induction
Insemination
Incidence
Fertilization in Vitro
Parity
Gynecology
Technology

Keywords

  • Assisted reproduction
  • Matched control study
  • Perinatal outcome

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Obstetric and neonatal risk of pregnancies after assisted reproductive technology : A matched control study. / Kozinsky, Zoltán; Zádori, János; Orvos, H.; Katona, M.; Pál, A.; Kovács, László.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 82, No. 9, 01.09.2003, p. 850-856.

Research output: Contribution to journalArticle

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abstract = "Background. The aim of the study was to evaluate the obstetric and neonatal outcome of pregnancies after assisted reproduction technology (ART) in comparison with matched controls from spontaneous pregnancies. Methods. A total of 12920 deliveries at the Department of Obstetrics and Gynecology, University of Szeged, from 1 January 1995 to 31 December 2001 were subjected to retrospective analysis. Two hundred and eighty-four singleton, 75 twin and 17 triplet pregnancies after ovulation induction (n = 114; 30.3{\%}), intrauterine insemination (n = 33; 8.8{\%}) and in vitro fertilization (n = 229; 60.9{\%}) were evaluated. The pregnancy outcome of the singleton and twin pregnancies was compared with that for controls matched with regard to age, gravidity and parity and previous obstetric outcome after spontaneous pregnancies. Results. Twenty-four percent of the assisted reproductive pregnancies were multiple pregnancies. The incidences of singleton intrauterine growth retardation (IUGR) and preterm birth were reasonably similar to those among the controls (IUGR: 6.3{\%} vs. 4.2{\%}; preterm births: 13.0{\%} vs. 9.9{\%}, for the cases and the controls, respectively). As compared with the controls, there was an increased incidence of cesarean section among the singleton (41.2{\%} vs. 34.5{\%}, p = 0.12; OR 1.33; 95{\%} CI 0.95-1.87) and twin assisted reproduction pregnancies (66.7{\%} vs. 60.0{\%}), but without significant differences. Conclusions. Increased obstetric risk could be observed concerning threatened preterm delivery and cesarean section rate in the study group. The perinatal outcome of singleton and twin pregnancies following assisted reproductive techniques is comparable with that of spontaneously conceived, matched pregnancies.",
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