Observations on NK cells, K cells and on their function a long time after posttraumatic splenectomy

J. Demeter, K. Paloczi, D. Lehoczky, M. Benczur

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Natural killer (NK) cell activity and antibody-dependent cellular cytotoxicity of 48 posttraumatic splenectomy patients was found to be normal despite the increase in the proportion and the absolute number of large granular lymphocytes (LGLs). The NK cell activity of 2 further posttraumatic splenectomy cases was severely decreased, despite elevated numbers of LGLs and normal number of CD16+ peripheral blood mononuclear cells. Besides increased susceptibility to upper respiratory tract infections, 1 of these patients developed herpes genitalis recidivans. Two posttraumatic splenectomy patients were found to have developed chronic lymphocytic leukemia 5 and 31 years following splenectomy, respectively.

Original languageEnglish
Pages (from-to)287-292
Number of pages6
JournalInternational Archives of Allergy and Applied Immunology
Volume92
Issue number3
Publication statusPublished - Dec 1 1990

ASJC Scopus subject areas

  • Immunology and Allergy

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