Objectively-measured and self-reported physical activity and fitness in relation to inflammatory markers in European adolescents

The HELENA Study

David Martinez-Gomez, Sonia Gomez-Martinez, Jonatan R. Ruiz, Ligia Esperanza Diaz, Francisco B. Ortega, Kurt Widhalm, Magdalena Cuenca-Garcia, Yannis Manios, Tineke De Vriendt, D. Molnár, Inge Huybrechts, Christina Breidenassel, Frederic Gottrand, Maria Plada, Sara Moreno, Marika Ferrari, Luis A. Moreno, Michael Sjöström, Ascension Marcos

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objective: Atherogenesis involves an inflammatory process that occurs early in life even though clinical symptoms are not observed until adulthood. Two important protective factors for low-grade inflammation may be physical activity (PA) and fitness. We examined the independent associations of objective and subjective measurements of PA and fitness with low-grade inflammation in European adolescents. Methods: A total of 1045 adolescents, aged from 12.5 to 17.5 years old from 10 European cities, were selected from the HELENA-Cross-Sectional Study. Objectively-measured and self-reported PA variables were obtained by accelerometry and the International PA Questionnaire for Adolescents, respectively. Overall, cardiorespiratory, muscular and motor fitness variables were assessed by standardized field-based fitness tests and the International Fitness Scale. C-reactive protein (CRP), complement factors 3 (C3) and 4 (C4), interleukin-6 and TNF-α inflammatory markers were measured. Results: Objectively-measured vigorous PA was inversely associated with C3 (β= -0.094, P= 0.021) but it did not remain significant after any objective fitness indicator was included in the model. Other objectively measured or self-reported assessments of PA were not significantly associated with inflammatory markers. All objective measures of fitness were inversely associated with CRP, C3 and C4, whereas only self-reported motor fitness remained significantly associated with C3, C4 and TNF-α. All these observations were independent of age, sex, city and body mass index or waist circumference. Conclusion: High PA in adolescence may play an indirect role on lessening low-grade inflammation through improvements in fitness.

Original languageEnglish
Pages (from-to)260-267
Number of pages8
JournalAtherosclerosis
Volume221
Issue number1
DOIs
Publication statusPublished - Mar 2012

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Physical Fitness
Exercise
Complement C3
Complement C4
Inflammation
C-Reactive Protein
Accelerometry
Waist Circumference
Interleukin-6
Atherosclerosis
Body Mass Index
Cross-Sectional Studies

Keywords

  • Adolescents
  • Inflammation
  • Physical activity
  • Physical fitness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Objectively-measured and self-reported physical activity and fitness in relation to inflammatory markers in European adolescents : The HELENA Study. / Martinez-Gomez, David; Gomez-Martinez, Sonia; Ruiz, Jonatan R.; Diaz, Ligia Esperanza; Ortega, Francisco B.; Widhalm, Kurt; Cuenca-Garcia, Magdalena; Manios, Yannis; De Vriendt, Tineke; Molnár, D.; Huybrechts, Inge; Breidenassel, Christina; Gottrand, Frederic; Plada, Maria; Moreno, Sara; Ferrari, Marika; Moreno, Luis A.; Sjöström, Michael; Marcos, Ascension.

In: Atherosclerosis, Vol. 221, No. 1, 03.2012, p. 260-267.

Research output: Contribution to journalArticle

Martinez-Gomez, D, Gomez-Martinez, S, Ruiz, JR, Diaz, LE, Ortega, FB, Widhalm, K, Cuenca-Garcia, M, Manios, Y, De Vriendt, T, Molnár, D, Huybrechts, I, Breidenassel, C, Gottrand, F, Plada, M, Moreno, S, Ferrari, M, Moreno, LA, Sjöström, M & Marcos, A 2012, 'Objectively-measured and self-reported physical activity and fitness in relation to inflammatory markers in European adolescents: The HELENA Study', Atherosclerosis, vol. 221, no. 1, pp. 260-267. https://doi.org/10.1016/j.atherosclerosis.2011.12.032
Martinez-Gomez, David ; Gomez-Martinez, Sonia ; Ruiz, Jonatan R. ; Diaz, Ligia Esperanza ; Ortega, Francisco B. ; Widhalm, Kurt ; Cuenca-Garcia, Magdalena ; Manios, Yannis ; De Vriendt, Tineke ; Molnár, D. ; Huybrechts, Inge ; Breidenassel, Christina ; Gottrand, Frederic ; Plada, Maria ; Moreno, Sara ; Ferrari, Marika ; Moreno, Luis A. ; Sjöström, Michael ; Marcos, Ascension. / Objectively-measured and self-reported physical activity and fitness in relation to inflammatory markers in European adolescents : The HELENA Study. In: Atherosclerosis. 2012 ; Vol. 221, No. 1. pp. 260-267.
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AU - Diaz, Ligia Esperanza

AU - Ortega, Francisco B.

AU - Widhalm, Kurt

AU - Cuenca-Garcia, Magdalena

AU - Manios, Yannis

AU - De Vriendt, Tineke

AU - Molnár, D.

AU - Huybrechts, Inge

AU - Breidenassel, Christina

AU - Gottrand, Frederic

AU - Plada, Maria

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N2 - Objective: Atherogenesis involves an inflammatory process that occurs early in life even though clinical symptoms are not observed until adulthood. Two important protective factors for low-grade inflammation may be physical activity (PA) and fitness. We examined the independent associations of objective and subjective measurements of PA and fitness with low-grade inflammation in European adolescents. Methods: A total of 1045 adolescents, aged from 12.5 to 17.5 years old from 10 European cities, were selected from the HELENA-Cross-Sectional Study. Objectively-measured and self-reported PA variables were obtained by accelerometry and the International PA Questionnaire for Adolescents, respectively. Overall, cardiorespiratory, muscular and motor fitness variables were assessed by standardized field-based fitness tests and the International Fitness Scale. C-reactive protein (CRP), complement factors 3 (C3) and 4 (C4), interleukin-6 and TNF-α inflammatory markers were measured. Results: Objectively-measured vigorous PA was inversely associated with C3 (β= -0.094, P= 0.021) but it did not remain significant after any objective fitness indicator was included in the model. Other objectively measured or self-reported assessments of PA were not significantly associated with inflammatory markers. All objective measures of fitness were inversely associated with CRP, C3 and C4, whereas only self-reported motor fitness remained significantly associated with C3, C4 and TNF-α. All these observations were independent of age, sex, city and body mass index or waist circumference. Conclusion: High PA in adolescence may play an indirect role on lessening low-grade inflammation through improvements in fitness.

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