(O-benzoylsalicylato)copper(II) complexes as synthetic enzyme-product models for flavonol 2,4-dioxygenase

J. Kaizer, Szabina Góger, G. Speier, Marius Réglier, Michel Giorgi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Mononuclear complexes of the type [CuII(BPEA)(O-bs)], [Cu II(BnBPA)(O-bs)]ClO4, and [CuII(Bn-6Me 2BPA)(O-bs)]ClO4 [O-bsH = O-benzoylsalicylic acid, BPEAH = N,N-bis(2-pyridylmethyl)amino-2-ethanoic acid, BnBPA = N-benzyl-N,N-bis(2- pyridylmethyl)amine, Bn-6Me2BPA = N-benzyl-N,N-bis(6-methyl-2- pyridylmethyl)amine] were synthesized as synthetic enzyme-depside complexes, and characterized by spectroscopic measurements and X-ray crystal analysis. The oxygenation of flavonol using the above-mentioned complexes as catalyst results in the oxidative cleavage of the heterocyclic ring to give a O-benzoylsalicylic acid and CO as a mimic of quercetinase action.

Original languageEnglish
Pages (from-to)251-254
Number of pages4
JournalInorganic Chemistry Communications
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 2006

Fingerprint

quercetin 2,3-dioxygenase
enzymes
Copper
Depsides
Amines
Enzymes
copper
acids
Acids
Oxygenation
amines
Carbon Monoxide
products
Acetic acid
oxygenation
X-Rays
X rays
Crystals
Catalysts
cleavage

Keywords

  • Carboxylates
  • Copper
  • Dioxygenation
  • Flavonol
  • O-Benzoylsalicylic acid

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

(O-benzoylsalicylato)copper(II) complexes as synthetic enzyme-product models for flavonol 2,4-dioxygenase. / Kaizer, J.; Góger, Szabina; Speier, G.; Réglier, Marius; Giorgi, Michel.

In: Inorganic Chemistry Communications, Vol. 9, No. 3, 03.2006, p. 251-254.

Research output: Contribution to journalArticle

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AU - Speier, G.

AU - Réglier, Marius

AU - Giorgi, Michel

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N2 - Mononuclear complexes of the type [CuII(BPEA)(O-bs)], [Cu II(BnBPA)(O-bs)]ClO4, and [CuII(Bn-6Me 2BPA)(O-bs)]ClO4 [O-bsH = O-benzoylsalicylic acid, BPEAH = N,N-bis(2-pyridylmethyl)amino-2-ethanoic acid, BnBPA = N-benzyl-N,N-bis(2- pyridylmethyl)amine, Bn-6Me2BPA = N-benzyl-N,N-bis(6-methyl-2- pyridylmethyl)amine] were synthesized as synthetic enzyme-depside complexes, and characterized by spectroscopic measurements and X-ray crystal analysis. The oxygenation of flavonol using the above-mentioned complexes as catalyst results in the oxidative cleavage of the heterocyclic ring to give a O-benzoylsalicylic acid and CO as a mimic of quercetinase action.

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