O-arylation of iodophenols with 2-fluorobenzaldehyde under microwave conditions

Erika Bálint, Mónika Kállai, Orsolya Kovács, Hedvig Bölcskei, György Keglevich

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The arylation of 4-iodo-, 2-iodo- and 3-iodophenols with 2-fluorobenzaldehyde may be carried out in the presence of K2CO 3 in DMF as the solvent under microwave conditions. The arylation of 4-iodophenole was promoted by the use of triethylbenzylammonium chloride (TEBAC) as the phase transfer catalyst. In the other model reactions, the use of TEBAC was harmful. By-products formed by isomerization and disproportionation were also detected.

Original languageEnglish
Pages (from-to)114-120
Number of pages7
JournalLetters in Drug Design and Discovery
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 1 2014

Keywords

  • 2-Flourobenzaldehyde
  • Arylation
  • Iodophenols
  • Microwave
  • Phase transfer catalysis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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