Nutritionally and chemically induced impairment of sulfate activation and sulfation of xenobiotics in vivo

Zoltán Gregus, Takiko Oguro, Curtis D. Klaassen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Sulfation requires 3′-phosphoadenosine 5′-phosphosulfate (PAPS) as the sulfate donor. In the search for methods to inhibit sulfation reactions via impairment of PAPS synthesis, two experimental conditions have been tested in rats. A low-sulfur diet, which does not deplete hepatic glutathione, reduced inorganic sulfate but not PAPS levels in the liver and moderately decreased sulfation of acetaminophen. Administration of molybdate, which is an alternative substrate for intestinal and renal sulfate transport as well as for ATP-sulfurylase, depleted both sulfate and PAPS in liver and markedly inhibited sulfation of acetaminophen. Therefore, administration of molybdate may be used as an experimental tool to study the role of sulfation in the fate and effect of xenobiotics.

Original languageEnglish
Pages (from-to)169-177
Number of pages9
JournalChemico-Biological Interactions
Volume92
Issue number1-3
DOIs
Publication statusPublished - Jun 1994

Keywords

  • 3′-Phosphoadenosine 5′-phosphosulfate
  • Acetaminophen
  • Molybdate
  • PAPS
  • Sulfate
  • Sulfation

ASJC Scopus subject areas

  • Toxicology

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