Nutritional Impact on Anabolic and Catabolic Signaling

M. Székely, Szilvia Soós, Erika Pétervári, M. Balaskó

Research output: Chapter in Book/Report/Conference proceedingChapter


Orexigenic and anorexigenic peptide signals from the gastrointestinal tract represent the feeding state for the CNS, while leptin and insulin convey information on the nutritional state-these together regulate body mass/composition. Primary changes in nutritional state modify this complex signaling: in obesity, resistance may develop to the anorexigenic signals (anorexigenic gastrointestinal peptides, leptin, insulin), while in calorie-restricted states no such resistance was demonstrated (as if promoting further obesity or maintenance of lean shape, respectively). The orexigenic signaling was less severely affected by the nutritional state. Aging may also be coupled with resistance to anorexigenic signals, contributing to the explanation of middle-aged obesity. Irrespective of the nutritional state in late phases of aging increased leptin sensitivity and enhanced catabolic mechanisms are characteristic.

Original languageEnglish
Title of host publicationMolecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series
PublisherElsevier Inc.
Number of pages16
ISBN (Electronic)9780128018279
ISBN (Print)9780128018163
Publication statusPublished - Apr 28 2016



  • Aging
  • Body mass
  • Energy balance
  • Food intake
  • Gastrointestinal peptides
  • Insulin
  • Leptin
  • Metabolic rate
  • Obesity
  • Undernutrition

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Székely, M., Soós, S., Pétervári, E., & Balaskó, M. (2016). Nutritional Impact on Anabolic and Catabolic Signaling. In Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series (pp. 189-204). Elsevier Inc..