Numerical modeling of capillary electrophoresis - Electrospray mass spectrometry interface design

Gabor Jarvas, Andras Guttman, Frantisek Foret

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Capillary electrophoresis hyphenated with electrospray mass spectrometry (CE-ESI-MS) has emerged in the past decade as one of the most powerful bioanalytical techniques. As the sensitivity and efficiency of new CE-ESI-MS interface designs are continuously improving, numerical modeling can play important role during their development. In this review, different aspects of computer modeling and simulation of CE-ESI-MS interfaces are comprehensively discussed. Relevant essentials of hydrodynamics as well as state-of-the-Art modeling techniques are critically evaluated. Sheath liquid-, sheathless-, and liquid-junction interfaces are reviewed from the viewpoint of multidisciplinary numerical modeling along with details of single and multiphase models together with electric field mediated flows, electrohydrodynamics, and free fluid-surface methods. Practical examples are given to help non-specialists to understand the basic principles and applications. Finally, alternative approaches like air amplifiers are also included.

Original languageEnglish
Pages (from-to)558-569
Number of pages12
JournalMass Spectrometry Reviews
Volume34
Issue number5
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • CE-ESI-MS
  • CFD
  • interface design
  • modeling
  • simulation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Condensed Matter Physics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Spectroscopy

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