Number of GABA immunonegative and GABA immunopositive neurons in human epileptic temporal cortex

Research output: Contribution to journalArticle

Abstract

The number of neurons, both GABA immunopositive and immunonegative, was determined in temporal epileptic foci of 7 patients after temporal lobectomy, and compared to neuronal numbers in temporal cortex of two controls taken from tumor operated patients. The thickness of the cortex of the epileptic cortex diminished by about 10%, while the number of nerve cells decreased to 67% of that of the control value: it was 19.000/mm3 vs. 28.000/mm3 found in the control. This decline was due to cell degeneration, which, however, was more severe for non-GABAergic nerve cells. Accordingly, the proportion of the GABA-positive neurons in the othervise diminished neuronal population increased to 36.4% from the 32% control value. The number of GABAergic terminals, however, decreased even further, explaining the resulting disinhibition during epileptic seizures.

Original languageEnglish
Pages (from-to)601-611
Number of pages11
JournalActa Biologica Hungarica
Volume53
Issue number4
DOIs
Publication statusPublished - 2002

Fingerprint

GABAergic Neurons
Temporal Lobe
tumor
gamma-Aminobutyric Acid
Neurons
cortex
neurons
Epilepsy
seizures
Population
Tumors
Neoplasms
neoplasms
seizure
cells

Keywords

  • Epilepsy
  • GABAergic neurons
  • Numerical density
  • Quantitative morphology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

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title = "Number of GABA immunonegative and GABA immunopositive neurons in human epileptic temporal cortex",
abstract = "The number of neurons, both GABA immunopositive and immunonegative, was determined in temporal epileptic foci of 7 patients after temporal lobectomy, and compared to neuronal numbers in temporal cortex of two controls taken from tumor operated patients. The thickness of the cortex of the epileptic cortex diminished by about 10{\%}, while the number of nerve cells decreased to 67{\%} of that of the control value: it was 19.000/mm3 vs. 28.000/mm3 found in the control. This decline was due to cell degeneration, which, however, was more severe for non-GABAergic nerve cells. Accordingly, the proportion of the GABA-positive neurons in the othervise diminished neuronal population increased to 36.4{\%} from the 32{\%} control value. The number of GABAergic terminals, however, decreased even further, explaining the resulting disinhibition during epileptic seizures.",
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