Nucleoside diphosphate kinases (NDPKs) in animal development

Krisztina Takács-Vellai, Tibor Vellai, Zsolt Farkas, Anil Mehta

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

In textbooks of biochemistry, nucleoside diphosphate conversion to a triphosphate by nucleoside diphosphate 'kinases' (NDPKs, also named NME or NM23 proteins) merits a few lines of text. Yet this essential metabolic function, mediated by a multimeric phosphotransferase protein, has effects that lie beyond a simple housekeeping role. NDPKs attracted more attention when NM23-H1 was identified as the first metastasis suppressor gene. In this review, we examine these NDPK enzymes from a developmental perspective because of the tractable phenotypes found in simple animal models that point to common themes. The data suggest that NDPK enzymes control the availability of surface receptors to regulate cell-sensing cues during cell migration. NDPKs regulate different forms of membrane enclosure that engulf dying cells during development. We suggest that NDPK enzymes have been essential for the regulated uptake of objects such as bacteria or micronutrients, and this evolutionarily conserved endocytic function contributes to their activity towards the regulation of metastasis.

Original languageEnglish
Pages (from-to)1447-1462
Number of pages16
JournalCellular and Molecular Life Sciences
Volume72
Issue number8
DOIs
Publication statusPublished - Apr 2015

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Keywords

  • Dynamin
  • Endocytosis
  • Engulfment
  • Metastasis inhibitor
  • NME
  • Nucleoside diphosphate kinases

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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