Nuclear translocation of heparan sulfate proteoglycans and their functional significance

I. Kovalszky, Anders Hjerpe, Katalin Dobra

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background Heparan sulfate proteoglycans (HSPGs) are important constituents of the cell membrane and they act as co-receptors for cellular signaling. Syndecan-1, glypican and perlecan also translocate to the nucleus in a regulated manner. Similar nuclear transport of growth factors and heparanase indicate a possible co-regulation and functional significance. Scope of review In this review we dissect the structural requirement for the nuclear translocation of HSPGs and their functional implications.s Major conclusions The functions of the nuclear HSPGs are still incompletely understood. Evidence point to possible functions in hampering cell proliferation, inhibition of DNA topoisomerase I activity and inhibition of gene transcription. General significance HSPGs influence the behavior of malignant tumors in many different ways. Modulating their functions may offer powerful tools to control fundamental biological processes and provide the basis for subsequent targeted therapies in cancer. This article is part of a Special Issue entitled Matrix-mediated cell behaviour and properties.

Original languageEnglish
Pages (from-to)2491-2497
Number of pages7
JournalBBA - General Subjects
Volume1840
Issue number8
DOIs
Publication statusPublished - 2014

Fingerprint

Heparan Sulfate Proteoglycans
Glypicans
Syndecan-1
Cell signaling
Biological Phenomena
Type I DNA Topoisomerase
Cell Nucleus Active Transport
Cell proliferation
Transcription
Cell membranes
Tumors
Neoplasms
Intercellular Signaling Peptides and Proteins
Genes
Cell Proliferation
Cell Membrane
Therapeutics

Keywords

  • Gene transcription
  • Heparan sulfate
  • Nuclear translocation
  • Proliferation
  • Proteoglycan

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Nuclear translocation of heparan sulfate proteoglycans and their functional significance. / Kovalszky, I.; Hjerpe, Anders; Dobra, Katalin.

In: BBA - General Subjects, Vol. 1840, No. 8, 2014, p. 2491-2497.

Research output: Contribution to journalArticle

Kovalszky, I. ; Hjerpe, Anders ; Dobra, Katalin. / Nuclear translocation of heparan sulfate proteoglycans and their functional significance. In: BBA - General Subjects. 2014 ; Vol. 1840, No. 8. pp. 2491-2497.
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