Nuclear Receptors in Immune Function

Mate Kiss, Laszlo Nagy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Immune cells have the capacity to respond to the changing extra- and intracellular lipid environment by altered gene expression and consequential changes in their phenotypes. The effects of many lipid molecules are mediated by a large group of ligand-activated transcription factors, termed nuclear receptors. These molecules are able to bind various lipids and modify gene expression that ultimately impacts cellular functions. In this article, we summarize our current understanding of the activity of a group of nuclear receptors with established roles in regulating the functions of immune cells including macrophages, dendritic cells, and lymphocytes. It appears that lipids have a major impact on immune cell activity and in this way provide a link between metabolic state and immune function. Also, some of these receptors are established or emerging drug targets in acute and chronic inflammatory diseases.

Original languageEnglish
Title of host publicationActivation of the Immune System
PublisherElsevier Inc.
Pages146-156
Number of pages11
Volume3
ISBN (Print)9780080921525
DOIs
Publication statusPublished - Apr 27 2016

Keywords

  • Glucocorticoid receptor
  • Immunity
  • Lipid
  • Liver x receptor
  • NR4A receptors
  • Nuclear receptor
  • Nur77
  • Peroxisome proliferator-associated receptor
  • Retinoic acid receptor
  • Retinoic acid receptor-related orphan receptor
  • Retinoid X receptor
  • Transcription
  • Vitamin D receptor

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Kiss, M., & Nagy, L. (2016). Nuclear Receptors in Immune Function. In Activation of the Immune System (Vol. 3, pp. 146-156). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374279-7.11012-4