Nuclear factor 1 (NF-1) binding sites in the genomes of human oncoviruses: a hypothetic role for reintegrated cellular origins of replication in malignant transformation

J. Minarovits, J. Segesdi, Z. Kovacs, I. Földes

Research output: Contribution to journalArticle

Abstract

We have found that genomes of human T cell leukemia-lymphoma virus type I (HTLV-I), BK virus (BKV), and a hepatitis B virus (HBV) DNA sequence integrated into DNA of a hepatoma-derived cell line contain binding sites for nuclear factor 1 (NF-1), a cellular protein which binds to adenoviral and putative cellular origins of DNA replication. We suggest that cellular origins of DNA replication acquired by oncoviruses may play a role in malignant transformation after reintegration into the cellular genome by providing new targets for cellular factors initiating DNA replication and by perturbing the temporal order of replication.

Original languageEnglish
Pages (from-to)27-29
Number of pages3
JournalMedical hypotheses
Volume25
Issue number1
DOIs
Publication statusPublished - Jan 1988

ASJC Scopus subject areas

  • Medicine(all)

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