Nε(γ-glutamyl)lysine in cerebrospinal fluid marks Alzheimer type and vascular dementia

Zoltán Nemes, László Fésüs, Anikó Égerházi, Adrienn Keszthelyi, István M. Degrell

Research output: Contribution to journalArticle

42 Citations (Scopus)


Nε(γ-glutamyl)lysine isodipeptide is released from the breakdown of proteins cross-linked by transglutaminase enzymes. Transglutaminase activation is a marker of apoptosis and elevated isodipeptide concentrations in body fluids might correlate with the intensity of apoptotic cell turnover. The concentration of Nε(γ-glutamyl)lysine was measured in the cerebrospinal fluid (CSF) of patients with probable Alzheimer's disease (n = 14) and vascular type dementia (n = 11) and compared with not demented surgical controls (n = 17). Baseline levels of 26-62 nM/l (mean 37.9 ± 8.7 SD) free isodipeptide were detected in control patients. CSF isodipeptide levels showed significant elevation in vascular (mean 95.6 ± 45.1 SD) as well as Alzheimer patients (176.6 ± 77.1 SD). Isodipeptide concentrations above 120 nM/l were 72% specific and 77% sensitive to Alzheimer's dementia, although the difference between the two dementias was statistically insignificant (p > 0.05). Determination of CSF Nε(γ-glutamyl)lysine isodipeptide concentration offers a novel method for measurement of neurodegeneration in primary and mixed dementias.

Original languageEnglish
Pages (from-to)403-406
Number of pages4
JournalNeurobiology of Aging
Issue number3
Publication statusPublished - Jun 18 2001


  • Alzheimer's dementia
  • Apoptosis
  • Transglutaminase
  • Vascular dementia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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