Nα-acetyl-[Arg8]vasopressin antagonizes the behavioral effect of [Cyt6]vasopressin-(5-9), but not of vasopressin

G. Kovács, Bin Liu, J. Peter H Burbach, Jan M. Van Ree, David De Wied

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

It has been found recently that Nα-acetyl-[Arg8]vasopressin (Ac-VP) is present in the brain of rats. The physiological significance of this peptide is as yet unknown. Therefore, the central nervous system effects of this peptide were investigated, namely, its effects on passive avoidance behavior, exploratory behavior and body temperature. The interaction of Ac-VP with the central nervous system effects of vasopressin (VP) was also studied. Ac-VP had a slight agonistic effect on passive avoidance behavior, i.e. it facilatated passive avoidance behavior at a dose 100 times higher than that of VP. Relatively low doses (3-10 ng) of Ac-VP attenuated passive avoidance behavior, which suggests that Ac-VP interfered with an endogenous compound involved in the control of passive avoidance responding. Ac-VP was also able, albeit in higher doses (30 ng), to competitively antagonize the effect of [Cyt6]VP-(5-9), a highly potent, putative endogenous metabolite of vasopressin in the rat brain. This antagonism could be due to an interaction of Ac-VP with sites other than the V1 vasopressin receptor. Ac-VP had no significant influence on other central nervous system effects of the hormonally active nonapeptide VP, such as exploratory behavior and body temperature. These effects were readily antagonized by the V1 vasopressin receptor antagonist d(CH2)5Tyr(Me)VP. Ac-VP may be a competitive antagonist of behaviorally active vasopressin metabolite(s) in the brain.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalEuropean Journal of Pharmacology
Volume161
Issue number1
DOIs
Publication statusPublished - Feb 14 1989

Fingerprint

Vasopressins
Avoidance Learning
Vasopressin Receptors
Exploratory Behavior
Central Nervous System
Body Temperature
Brain
Peptides

Keywords

  • Acetyl-vasopressin
  • Body temperature
  • Exploratory behavior
  • Passive avoidance behavior
  • Vasopressin
  • [Cyt]vasopressin-(5-9)

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Nα-acetyl-[Arg8]vasopressin antagonizes the behavioral effect of [Cyt6]vasopressin-(5-9), but not of vasopressin. / Kovács, G.; Liu, Bin; Burbach, J. Peter H; Van Ree, Jan M.; De Wied, David.

In: European Journal of Pharmacology, Vol. 161, No. 1, 14.02.1989, p. 27-35.

Research output: Contribution to journalArticle

Kovács, G. ; Liu, Bin ; Burbach, J. Peter H ; Van Ree, Jan M. ; De Wied, David. / Nα-acetyl-[Arg8]vasopressin antagonizes the behavioral effect of [Cyt6]vasopressin-(5-9), but not of vasopressin. In: European Journal of Pharmacology. 1989 ; Vol. 161, No. 1. pp. 27-35.
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