Novelty response of rats determines the effect of prefrontal alpha-2 adrenoceptor modulation on anxiety

B. Uzsoki, M. Tóth, I. Hernádi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this study we provide evidence that animals of the same population, although identical in age and sex, have individual reactions to the prefrontal modulation of adrenoceptors. We have examined the dose-dependent action of α2-adrenoceptor agents on the anxiety of rats with different response to novelty in the elevated plus maze (EPM) apparatus. Rats were divided into high (HR) and low responder (LR) groups based on their locomotor activity in a novel open field environment. HR rats also showed increased locomotion and low anxiety in the EPM. Prefrontal injection of α2-receptor antagonist yohimbine, BRL44408 or imiloxan caused anxiety only in HR rats. The α2A/D-receptor agonist guanfacine increased anxiety levels of both groups. However, the effective dose was lower in HR rats. The present results propose different prefrontal adrenoceptor sensitivity of rats showing distinct baseline activity levels.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalNeuroscience Letters
Volume499
Issue number3
DOIs
Publication statusPublished - Jul 25 2011

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Adrenergic Receptors
Anxiety
Locomotion
Guanfacine
Yohimbine
Injections
Population

Keywords

  • α adrenergic receptor
  • Elevated plus maze
  • Intracerebral injection
  • Novelty response
  • Prefrontal cortex
  • Trait anxiety

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Novelty response of rats determines the effect of prefrontal alpha-2 adrenoceptor modulation on anxiety. / Uzsoki, B.; Tóth, M.; Hernádi, I.

In: Neuroscience Letters, Vol. 499, No. 3, 25.07.2011, p. 219-223.

Research output: Contribution to journalArticle

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