Novel therapeutic strategies for cardioprotection

Joost P.G. Sluijter, Gianluigi Condorelli, Sean M. Davidson, Felix B. Engel, Peter Ferdinandy, Derek J. Hausenloy, Sandrine Lecour, Rosalinda Madonna, Michel Ovize, Marisol Ruiz-Meana, Rainer Schulz, Linda W. Van Laake

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

The morbidity and mortality from ischemic heart disease (IHD) remain significant worldwide. The treatment for acute myocardial infarction has improved over the past decades, including early reperfusion of occluded coronary arteries. Although it is essential to re-open the artery as soon as possible, paradoxically this leads to additional myocardial injury, called acute ischemia-reperfusion injury (IRI), for which currently no effective therapy is available. Therefore, novel therapeutic strategies are required to protect the heart from acute IRI in order to reduce myocardial infarction size, preserve cardiac function and improve clinical outcomes in patients with IHD. In this review article, we will first outline the pathophysiology of acute IRI and review promising therapeutic strategies for cardioprotection. These include novel aspects of mitochondrial function, epigenetics, circadian clocks, the immune system, microvesicles, growth factors, stem cell therapy and gene therapy. We discuss the therapeutic potential of these novel cardioprotective strategies in terms of pharmacological targeting and clinical application.

Original languageEnglish
Pages (from-to)60-70
Number of pages11
JournalPharmacology and Therapeutics
Volume144
Issue number1
DOIs
Publication statusPublished - Oct 2014

Keywords

  • Cardioprotection
  • Circadian clock
  • Growth factors
  • Ischemia-reperfusion injury
  • Microvesicles
  • Mitochondria

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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  • Cite this

    Sluijter, J. P. G., Condorelli, G., Davidson, S. M., Engel, F. B., Ferdinandy, P., Hausenloy, D. J., Lecour, S., Madonna, R., Ovize, M., Ruiz-Meana, M., Schulz, R., & Van Laake, L. W. (2014). Novel therapeutic strategies for cardioprotection. Pharmacology and Therapeutics, 144(1), 60-70. https://doi.org/10.1016/j.pharmthera.2014.05.005