Novel therapeutic strategies for cardioprotection

Joost P G Sluijter, Gianluigi Condorelli, Sean M. Davidson, Felix B. Engel, P. Ferdinándy, Derek J. Hausenloy, Sandrine Lecour, Rosalinda Madonna, Michel Ovize, Marisol Ruiz-Meana, Rainer Schulz, Linda W. Van Laake

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The morbidity and mortality from ischemic heart disease (IHD) remain significant worldwide. The treatment for acute myocardial infarction has improved over the past decades, including early reperfusion of occluded coronary arteries. Although it is essential to re-open the artery as soon as possible, paradoxically this leads to additional myocardial injury, called acute ischemia-reperfusion injury (IRI), for which currently no effective therapy is available. Therefore, novel therapeutic strategies are required to protect the heart from acute IRI in order to reduce myocardial infarction size, preserve cardiac function and improve clinical outcomes in patients with IHD. In this review article, we will first outline the pathophysiology of acute IRI and review promising therapeutic strategies for cardioprotection. These include novel aspects of mitochondrial function, epigenetics, circadian clocks, the immune system, microvesicles, growth factors, stem cell therapy and gene therapy. We discuss the therapeutic potential of these novel cardioprotective strategies in terms of pharmacological targeting and clinical application.

Original languageEnglish
Pages (from-to)60-70
Number of pages11
JournalPharmacology and Therapeutics
Volume144
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Reperfusion Injury
Myocardial Ischemia
Myocardial Infarction
Therapeutics
Circadian Clocks
Cell- and Tissue-Based Therapy
Epigenomics
Genetic Therapy
Reperfusion
Immune System
Intercellular Signaling Peptides and Proteins
Coronary Vessels
Stem Cells
Arteries
Pharmacology
Morbidity
Mortality
Wounds and Injuries

Keywords

  • Cardioprotection
  • Circadian clock
  • Growth factors
  • Ischemia-reperfusion injury
  • Microvesicles
  • Mitochondria

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Medicine(all)

Cite this

Sluijter, J. P. G., Condorelli, G., Davidson, S. M., Engel, F. B., Ferdinándy, P., Hausenloy, D. J., ... Van Laake, L. W. (2014). Novel therapeutic strategies for cardioprotection. Pharmacology and Therapeutics, 144(1), 60-70. https://doi.org/10.1016/j.pharmthera.2014.05.005

Novel therapeutic strategies for cardioprotection. / Sluijter, Joost P G; Condorelli, Gianluigi; Davidson, Sean M.; Engel, Felix B.; Ferdinándy, P.; Hausenloy, Derek J.; Lecour, Sandrine; Madonna, Rosalinda; Ovize, Michel; Ruiz-Meana, Marisol; Schulz, Rainer; Van Laake, Linda W.

In: Pharmacology and Therapeutics, Vol. 144, No. 1, 2014, p. 60-70.

Research output: Contribution to journalArticle

Sluijter, JPG, Condorelli, G, Davidson, SM, Engel, FB, Ferdinándy, P, Hausenloy, DJ, Lecour, S, Madonna, R, Ovize, M, Ruiz-Meana, M, Schulz, R & Van Laake, LW 2014, 'Novel therapeutic strategies for cardioprotection', Pharmacology and Therapeutics, vol. 144, no. 1, pp. 60-70. https://doi.org/10.1016/j.pharmthera.2014.05.005
Sluijter JPG, Condorelli G, Davidson SM, Engel FB, Ferdinándy P, Hausenloy DJ et al. Novel therapeutic strategies for cardioprotection. Pharmacology and Therapeutics. 2014;144(1):60-70. https://doi.org/10.1016/j.pharmthera.2014.05.005
Sluijter, Joost P G ; Condorelli, Gianluigi ; Davidson, Sean M. ; Engel, Felix B. ; Ferdinándy, P. ; Hausenloy, Derek J. ; Lecour, Sandrine ; Madonna, Rosalinda ; Ovize, Michel ; Ruiz-Meana, Marisol ; Schulz, Rainer ; Van Laake, Linda W. / Novel therapeutic strategies for cardioprotection. In: Pharmacology and Therapeutics. 2014 ; Vol. 144, No. 1. pp. 60-70.
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