Új lehetoség az agyi áttétek sugárkezelésében: Együttesen alkalmazott teljeskoponya-besugárzás és integrált sztereotaxiás sugársebészeti ellátás

Translated title of the contribution: Novel strategy in the radiotherapy of metastatic brain tumors: Simultaneous whole brain radiotherapy and integrated stereotactic radiosurgery

Judit Kalincsák, Zoltán László, Zsolt Sebestyén, Péter Kovács, Zsolt Horváth, T. Dóczi, László Mangel

Research output: Contribution to journalArticle

Abstract

Background and purpose: Treatment of central nervous system (CNS) tumors has always played an important role in development of radiotherapy techniques. Precise patient immobilisation, non-coplanar field arrangement, conformai treatment, arc therapy, radiosurgery, application of image fusion to radiation planning or re-irradiation were first introduced into clinical routine in the treatment of brain tumors. Methods: A modern multifunctional radiation instrument, Novalis TX has been installed at the University of Pécs two years ago. New methods, such as real time 3D image guided therapy, dynamic arc therapy and ultra-conformity offer further progress in treatment of CNS tumors. Whole brain irradiation and simultaneous fractionated stereotactic radiosurgery or integrated boost seem to be an optimal method in the treatment of not only soliter or oligo, but even a higher number (4-9) and not typically radiosensitive brain metastases. The new treatment strategy is illustrated by presentation of four case histories. Results: Treatment protocol was completed in all cases. Treatment period of 1.5 to 3 weeks, and treatment time of only a few minutes were not stressful for the patients. A quite remarkable clinical improvement as to general condition of the patients was experienced in three cases. Followup images confirmed either remission or a stable disease. Conclusions: Simultaneous whole brain radiotherapy and integrated stereotactic radiosurgery is a reproducible, safe method that offers an effective irradiation with delivery of definitive dosage even in cases with radio-insensitive brain metastasis.

Original languageHungarian
Pages (from-to)391-397
Number of pages7
JournalIdeggyogyaszati Szemle
Volume68
Issue number11-12
DOIs
Publication statusPublished - Nov 30 2015

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Radiosurgery
Brain Neoplasms
Radiotherapy
Brain
Therapeutics
Central Nervous System Neoplasms
Radiation
Neoplasm Metastasis
Clinical Protocols
Radio
Immobilization

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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Új lehetoség az agyi áttétek sugárkezelésében : Együttesen alkalmazott teljeskoponya-besugárzás és integrált sztereotaxiás sugársebészeti ellátás. / Kalincsák, Judit; László, Zoltán; Sebestyén, Zsolt; Kovács, Péter; Horváth, Zsolt; Dóczi, T.; Mangel, László.

In: Ideggyogyaszati Szemle, Vol. 68, No. 11-12, 30.11.2015, p. 391-397.

Research output: Contribution to journalArticle

Kalincsák, Judit ; László, Zoltán ; Sebestyén, Zsolt ; Kovács, Péter ; Horváth, Zsolt ; Dóczi, T. ; Mangel, László. / Új lehetoség az agyi áttétek sugárkezelésében : Együttesen alkalmazott teljeskoponya-besugárzás és integrált sztereotaxiás sugársebészeti ellátás. In: Ideggyogyaszati Szemle. 2015 ; Vol. 68, No. 11-12. pp. 391-397.
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AU - Kalincsák, Judit

AU - László, Zoltán

AU - Sebestyén, Zsolt

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AU - Horváth, Zsolt

AU - Dóczi, T.

AU - Mangel, László

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