Novel steroid derivative modulates gene expression of cytokines and growth regulators

G. Michel, K. Nowok, A. Beetz, C. Ried, L. Kemeny, T. Ruzicka

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Topical steroid treatment is a common therapy for psoriasis. Steroids are known to bind to specific cytoplasmic receptors and to influence gene expression. We investigated the effects of the novel steroid derivative mometasone furoate on the expression of putative target genes in normal human epidermal cells (KC). Gene expression was measured by semiquantitative mRNA-PCR. In addition, cytokine receptor characteristics were assessed by ligand binding studies. We found a dose-dependent downregulation of proinflammatory mediators (IL-8, TNFα). Genes involved in growth regulation (HER-2, p53) were also modulated. IL-8 binding to KC was inhibited. We conclude that modulation of the expression of cytokine, cytokine receptor and growth factor genes may contribute to the antipsoriatic action of steroids.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalSkin Pharmacology
Volume8
Issue number5
DOIs
Publication statusPublished - Jan 1 1995

Keywords

  • HER-2
  • IL-8
  • Psoriasis
  • Steroids
  • TNFα
  • p53

ASJC Scopus subject areas

  • Dermatology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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