Novel SO3H functionalized magnetic nanoporous silica/polymer nanocomposite as a carrier in a dual-drug delivery system for anticancer therapy

Margarita Popova, Ivalina Trendafilova, A. Szegedi, Denitsa Momekova, J. Mihály, Georgi Momekov, László F. Kiss, K. Lázár, Neli Koseva

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Magnetic nanoporous silica particles (MNS) with spherical morphology and 100 nm particle with advanced characteristics suitable for nanomedicine purposes were synthesized. The obtained nanoparticles were modified with SO3H groups in a two-step post synthesis procedure. An anticancer drug, mitoxantrone (MTX), and an anti-inflammatory drug, prednisolone (PRD), were loaded on the silica support. The mitoxantrone loaded MNS-SO3H nanoparticles were coated by chitosan and then prednisolone was infused in the chitosan layer. A second layer of alginate was then applied around the prednisolone and mitoxantrone containing formulation. All materials were characterized by XRD, N2 physisorption, Mössbauer spectroscopy, magnetization measurements and transmission electron microscopy in order to demonstrate that by the applied preparation method around 11 nm sized maghemite crystals embedded in spherical mesoporous silica nanoparticles were obtained with high pore volume and surface area. Thermal gravimetric analysis, ATR FT-IR spectroscopy and in vitro release experiments proved that MTX and PRD were successfully loaded on the silica matrix. Alginate coating further improved the release properties by preventing the burst release of MTX and PRD. The cytotoxicity properties of the drugs loaded formulations and their ability to retain the intrinsic pharmacological properties of the encapsulated drugs were investigated on a panel of human tumor cell lines.

Original languageEnglish
Pages (from-to)96-105
Number of pages10
JournalMicroporous and Mesoporous Materials
Volume263
DOIs
Publication statusPublished - Jun 1 2018

Fingerprint

Mitoxantrone
Prednisolone
Silicon Dioxide
therapy
delivery
Nanocomposites
nanocomposites
Polymers
drugs
Silica
silicon dioxide
polymers
Alginate
Chitosan
Nanoparticles
nanoparticles
Pharmaceutical Preparations
Medical nanotechnology
formulations
Physisorption

Keywords

  • Anticancer therapy
  • Controlled release
  • Magnetic nanoporous silica
  • Mitoxantrone
  • Prednisolone

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials

Cite this

Novel SO3H functionalized magnetic nanoporous silica/polymer nanocomposite as a carrier in a dual-drug delivery system for anticancer therapy. / Popova, Margarita; Trendafilova, Ivalina; Szegedi, A.; Momekova, Denitsa; Mihály, J.; Momekov, Georgi; Kiss, László F.; Lázár, K.; Koseva, Neli.

In: Microporous and Mesoporous Materials, Vol. 263, 01.06.2018, p. 96-105.

Research output: Contribution to journalArticle

Popova, Margarita ; Trendafilova, Ivalina ; Szegedi, A. ; Momekova, Denitsa ; Mihály, J. ; Momekov, Georgi ; Kiss, László F. ; Lázár, K. ; Koseva, Neli. / Novel SO3H functionalized magnetic nanoporous silica/polymer nanocomposite as a carrier in a dual-drug delivery system for anticancer therapy. In: Microporous and Mesoporous Materials. 2018 ; Vol. 263. pp. 96-105.
@article{c34d9d3699714a28888d7a06f6387800,
title = "Novel SO3H functionalized magnetic nanoporous silica/polymer nanocomposite as a carrier in a dual-drug delivery system for anticancer therapy",
abstract = "Magnetic nanoporous silica particles (MNS) with spherical morphology and 100 nm particle with advanced characteristics suitable for nanomedicine purposes were synthesized. The obtained nanoparticles were modified with SO3H groups in a two-step post synthesis procedure. An anticancer drug, mitoxantrone (MTX), and an anti-inflammatory drug, prednisolone (PRD), were loaded on the silica support. The mitoxantrone loaded MNS-SO3H nanoparticles were coated by chitosan and then prednisolone was infused in the chitosan layer. A second layer of alginate was then applied around the prednisolone and mitoxantrone containing formulation. All materials were characterized by XRD, N2 physisorption, M{\"o}ssbauer spectroscopy, magnetization measurements and transmission electron microscopy in order to demonstrate that by the applied preparation method around 11 nm sized maghemite crystals embedded in spherical mesoporous silica nanoparticles were obtained with high pore volume and surface area. Thermal gravimetric analysis, ATR FT-IR spectroscopy and in vitro release experiments proved that MTX and PRD were successfully loaded on the silica matrix. Alginate coating further improved the release properties by preventing the burst release of MTX and PRD. The cytotoxicity properties of the drugs loaded formulations and their ability to retain the intrinsic pharmacological properties of the encapsulated drugs were investigated on a panel of human tumor cell lines.",
keywords = "Anticancer therapy, Controlled release, Magnetic nanoporous silica, Mitoxantrone, Prednisolone",
author = "Margarita Popova and Ivalina Trendafilova and A. Szegedi and Denitsa Momekova and J. Mih{\'a}ly and Georgi Momekov and Kiss, {L{\'a}szl{\'o} F.} and K. L{\'a}z{\'a}r and Neli Koseva",
year = "2018",
month = "6",
day = "1",
doi = "10.1016/j.micromeso.2017.12.005",
language = "English",
volume = "263",
pages = "96--105",
journal = "Microporous and Mesoporous Materials",
issn = "1387-1811",
publisher = "Elsevier",

}

TY - JOUR

T1 - Novel SO3H functionalized magnetic nanoporous silica/polymer nanocomposite as a carrier in a dual-drug delivery system for anticancer therapy

AU - Popova, Margarita

AU - Trendafilova, Ivalina

AU - Szegedi, A.

AU - Momekova, Denitsa

AU - Mihály, J.

AU - Momekov, Georgi

AU - Kiss, László F.

AU - Lázár, K.

AU - Koseva, Neli

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Magnetic nanoporous silica particles (MNS) with spherical morphology and 100 nm particle with advanced characteristics suitable for nanomedicine purposes were synthesized. The obtained nanoparticles were modified with SO3H groups in a two-step post synthesis procedure. An anticancer drug, mitoxantrone (MTX), and an anti-inflammatory drug, prednisolone (PRD), were loaded on the silica support. The mitoxantrone loaded MNS-SO3H nanoparticles were coated by chitosan and then prednisolone was infused in the chitosan layer. A second layer of alginate was then applied around the prednisolone and mitoxantrone containing formulation. All materials were characterized by XRD, N2 physisorption, Mössbauer spectroscopy, magnetization measurements and transmission electron microscopy in order to demonstrate that by the applied preparation method around 11 nm sized maghemite crystals embedded in spherical mesoporous silica nanoparticles were obtained with high pore volume and surface area. Thermal gravimetric analysis, ATR FT-IR spectroscopy and in vitro release experiments proved that MTX and PRD were successfully loaded on the silica matrix. Alginate coating further improved the release properties by preventing the burst release of MTX and PRD. The cytotoxicity properties of the drugs loaded formulations and their ability to retain the intrinsic pharmacological properties of the encapsulated drugs were investigated on a panel of human tumor cell lines.

AB - Magnetic nanoporous silica particles (MNS) with spherical morphology and 100 nm particle with advanced characteristics suitable for nanomedicine purposes were synthesized. The obtained nanoparticles were modified with SO3H groups in a two-step post synthesis procedure. An anticancer drug, mitoxantrone (MTX), and an anti-inflammatory drug, prednisolone (PRD), were loaded on the silica support. The mitoxantrone loaded MNS-SO3H nanoparticles were coated by chitosan and then prednisolone was infused in the chitosan layer. A second layer of alginate was then applied around the prednisolone and mitoxantrone containing formulation. All materials were characterized by XRD, N2 physisorption, Mössbauer spectroscopy, magnetization measurements and transmission electron microscopy in order to demonstrate that by the applied preparation method around 11 nm sized maghemite crystals embedded in spherical mesoporous silica nanoparticles were obtained with high pore volume and surface area. Thermal gravimetric analysis, ATR FT-IR spectroscopy and in vitro release experiments proved that MTX and PRD were successfully loaded on the silica matrix. Alginate coating further improved the release properties by preventing the burst release of MTX and PRD. The cytotoxicity properties of the drugs loaded formulations and their ability to retain the intrinsic pharmacological properties of the encapsulated drugs were investigated on a panel of human tumor cell lines.

KW - Anticancer therapy

KW - Controlled release

KW - Magnetic nanoporous silica

KW - Mitoxantrone

KW - Prednisolone

UR - http://www.scopus.com/inward/record.url?scp=85037982656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85037982656&partnerID=8YFLogxK

U2 - 10.1016/j.micromeso.2017.12.005

DO - 10.1016/j.micromeso.2017.12.005

M3 - Article

AN - SCOPUS:85037982656

VL - 263

SP - 96

EP - 105

JO - Microporous and Mesoporous Materials

JF - Microporous and Mesoporous Materials

SN - 1387-1811

ER -