Novel NSP4 genotype in a camel G10P[15] rotavirus strain

Hajnalka Papp, Laila Al-Mutairi, Wassim Chehadeh, Szilvia Farkas, György Lengyel, Ferenc Jakab, Vito Martella, György Szucs, Krisztián Bányai

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In this study a Kuwaiti camel rotavirus strain, RVA/Camel-wt/KUW/s21/2010/ G10P[15], is characterized by sequencing and phylogenetic analysis. The strain had multiple genes with high nucleotide sequence similarities to ovine and bovine strains (VP2, ≤ 96%; NSP2 and NSP5, ≤ 97%, NSP3, ≤ 94%), or, to porcine strains (VP1, ≤ 89%). Other genes had moderate sequence similarities (VP4, ≤ 87%; VP6, ≤ 81%; VP7, ≤ 82%) with reference strains from ruminants. The NSP4 gene shared limited sequence identity (≤ 71%) with other mammalian and avian rotavirus NSP4 types, and was designated a novel genotype, E15. This study demonstrates genetic diversity in the outer capsid and some backbone genes of an old-world camelid rotavirus strain and uncovers its common evolutionary roots with strains from other ruminants.

Original languageEnglish
Pages (from-to)411-421
Number of pages11
JournalActa microbiologica et immunologica Hungarica
Volume59
Issue number3
DOIs
Publication statusPublished - Sep 1 2012

Keywords

  • Camelus dromedarius
  • Kuwait
  • dromedary rotavirus
  • genotyping
  • phylogenetic analysis

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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    Papp, H., Al-Mutairi, L., Chehadeh, W., Farkas, S., Lengyel, G., Jakab, F., Martella, V., Szucs, G., & Bányai, K. (2012). Novel NSP4 genotype in a camel G10P[15] rotavirus strain. Acta microbiologica et immunologica Hungarica, 59(3), 411-421. https://doi.org/10.1556/AMicr.59.2012.3.11