Novel neuroprotective strategies in ischemic retinal lesions

K. Szabadfi, Laszlo Mester, D. Reglodi, P. Kiss, Norbert Babai, B. Rácz, Krisztina Kovacs, A. Szabó, Aliz Tamas, R. Gábriel, Tamas Atlasz

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Retinal ischemia can be effectively modeled by permanent bilateral common carotid artery occlusion, which leads to chronic hypoperfusion-induced degeneration in the entire rat retina. The complex pathways leading to retinal cell death offer a complex approach of neuroprotective strategies. In the present review we summarize recent findings with different neuroprotective candidate molecules. We describe the protective effects of intravitreal treatment with: (i) urocortin 2; (ii) a mitochondrial ATP-sensitive K + channel opener, diazoxide; (iii) a neurotrophic factor, pituitary adenylate cyclase activating polypeptide; and (iv) a novel poly(ADP-ribose) polymerase inhibitor (HO3089). The retinoprotective effects are demonstrated with morphological description and effects on apoptotic pathways using molecular biological techniques.

Original languageEnglish
Pages (from-to)544-561
Number of pages18
JournalInternational Journal of Molecular Sciences
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Urocortins
Pituitary Adenylate Cyclase-Activating Polypeptide
Diazoxide
Administrative data processing
Adenosinetriphosphate
Common Carotid Artery
Nerve Growth Factors
Cell death
lesions
Retina
Rats
Cell Death
Ischemia
Adenosine Triphosphate
Molecules
ribose
ischemia
adenosine diphosphate
degeneration
retina

Keywords

  • BCCAO
  • Diazoxide
  • Ischemia
  • PACAP
  • PARP-inhibitor
  • Rat retina
  • Retinoprotection
  • Urocortin 2

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Novel neuroprotective strategies in ischemic retinal lesions. / Szabadfi, K.; Mester, Laszlo; Reglodi, D.; Kiss, P.; Babai, Norbert; Rácz, B.; Kovacs, Krisztina; Szabó, A.; Tamas, Aliz; Gábriel, R.; Atlasz, Tamas.

In: International Journal of Molecular Sciences, Vol. 11, No. 2, 02.2010, p. 544-561.

Research output: Contribution to journalArticle

Szabadfi, K. ; Mester, Laszlo ; Reglodi, D. ; Kiss, P. ; Babai, Norbert ; Rácz, B. ; Kovacs, Krisztina ; Szabó, A. ; Tamas, Aliz ; Gábriel, R. ; Atlasz, Tamas. / Novel neuroprotective strategies in ischemic retinal lesions. In: International Journal of Molecular Sciences. 2010 ; Vol. 11, No. 2. pp. 544-561.
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