Novel methods for the stereoselective synthesis of oxetane, azetidine and pyrrolidine derivatives

F. Faigl, E. Kovács, G. Turczel, L. Hegedûs, A. Thurner, F. Farkas, A. Szöllösy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Novel, superbase promoted stereoselective rearrangement reactions of chiral oxirane derivatives provided chiral oxetane and azetidine derivatives. An optically active 3,4-disubstituted pyrrolidine was synthetised via catalytic hydrogenolysis of an oxetane derivative followed by ring closure of the formed optically active aminoalcohol.

Original languageEnglish
Title of host publicationIFMBE Proceedings
Pages1366-1369
Number of pages4
Volume37
DOIs
Publication statusPublished - 2011

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Derivatives
Ethylene Oxide
Hydrogenolysis
pyrrolidine
oxetane
azetidine

Keywords

  • azetidine
  • hydrogenolysis
  • oxetane
  • pyrrolidine
  • Stereoselective rearrangement
  • superbase

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Novel methods for the stereoselective synthesis of oxetane, azetidine and pyrrolidine derivatives. / Faigl, F.; Kovács, E.; Turczel, G.; Hegedûs, L.; Thurner, A.; Farkas, F.; Szöllösy, A.

IFMBE Proceedings. Vol. 37 2011. p. 1366-1369.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Faigl, F. ; Kovács, E. ; Turczel, G. ; Hegedûs, L. ; Thurner, A. ; Farkas, F. ; Szöllösy, A. / Novel methods for the stereoselective synthesis of oxetane, azetidine and pyrrolidine derivatives. IFMBE Proceedings. Vol. 37 2011. pp. 1366-1369
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