Novel mastadenovirus infection and clinical disease in a pygmy marmoset (Callithrix [Cebuella] pygmaea)

János Gál, A. Hornyák, Míra Mándoki, Tamás Bakonyi, Gyula Balka, Levente Szeredi, Miklós Marosán, Tibor Ludányi, Petra Forgách, Endre Sós, Zoltán Demeter, Szilvia L. Farkas

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11 Citations (Scopus)

Abstract

We describe the detection and successful isolation of a novel mastadenovirus from a pygmy marmoset ( Callithrix [Cebuella] pygmaea) that died following an episode of severe respiratory signs. Pathologic/histopathologic examination revealed hydrothorax and catarrhal bronchopneumonia with pronounced desquamation of the bronchiolar epithelial cells, while in other airways a marked hyperplasia of the epithelial lining and numerous giant cells could be observed. We obtained partial sequence data from the adenoviral DNA-dependent DNA-polymerase gene of the isolated strain and analyses of this region showed the highest level of identity to the recently described bat adenoviruses (strains PPV1 and TJM) and the type 2 canine adenovirus. Similar results were gained by phylogenetic calculations indicating that this novel marmoset adenovirus is only distantly related to reference Old and New World primate adenoviruses and formed a monophyletic group with bat and canine adenoviruses and the equine adenovirus 1. Even though the source of the infection remained unknown, our results could imply the possibility of a cross-species transmission of the virus from an anonymous host to the pygmy marmoset.

Original languageEnglish
Pages (from-to)695-699
Number of pages5
JournalVeterinary Microbiology
Volume167
Issue number3-4
DOIs
Publication statusPublished - Dec 27 2013

Keywords

  • Adenoviridae
  • Callithrix (Cebuella) pygmaea
  • Mastadenovirus
  • Pygmy marmoset

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)

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  • Cite this

    Gál, J., Hornyák, A., Mándoki, M., Bakonyi, T., Balka, G., Szeredi, L., Marosán, M., Ludányi, T., Forgách, P., Sós, E., Demeter, Z., & Farkas, S. L. (2013). Novel mastadenovirus infection and clinical disease in a pygmy marmoset (Callithrix [Cebuella] pygmaea). Veterinary Microbiology, 167(3-4), 695-699. https://doi.org/10.1016/j.vetmic.2013.08.008