Novel ICD programming and inappropriate ICD therapy in CRT-D versus ICD patients

A MADIT-RIT sub-study

Valentina Kutyifa, James P. Daubert, Claudio Schuger, Ilan Goldenberg, Helmut Klein, Mehmet K. Aktas, Scott McNitt, Martin Stockburger, B. Merkely, Wojciech Zareba, Arthur J. Moss

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background-The Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate therapy (MADIT-RIT) trial showed a significant reduction in inappropriate implantable cardioverter defibrillator (ICD) therapy in patients programmed to high-rate cut-off (Arm B) or delayed ventricular tachycardia therapy (Arm C), compared with conventional programming (Arm A). There is limited data on the effect of cardiac resynchronization therapy with a cardioverter defibrillator (CRT-D) on the effect of ICD programming. We aimed to elucidate the effect of CRT-D on ICD programming to reduce inappropriate ICD therapy in patients implanted with CRT-D or an ICD, enrolled in MADIT-RIT. Methods and Results-The primary end point of this study was the first inappropriate ICD therapy. Secondary end points were inappropriate anti-tachycardia pacing and inappropriate ICD shock. The study enrolled 742 (49%) patients with an ICD and 757 (51%) patients with a CRT-D. Patients implanted with a CRT-D had 62% lower risk of inappropriate ICD therapy than those with an ICD only (hazard ratio [HR] =0.38, 95% confidence interval: 0.25-0.57; P

Original languageEnglish
Article numbere001965
JournalCirculation: Arrhythmia and Electrophysiology
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Defibrillators
Implantable Defibrillators
Therapeutics
Cardiac Resynchronization Therapy
Ventricular Tachycardia
Tachycardia
Shock
Confidence Intervals

Keywords

  • Atrial fibrillation
  • Cardiac resynchronization therapy
  • ICD Programming
  • Implantable cardioverter-defibrillator
  • MADIT-RIT
  • supraventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Kutyifa, V., Daubert, J. P., Schuger, C., Goldenberg, I., Klein, H., Aktas, M. K., ... Moss, A. J. (2016). Novel ICD programming and inappropriate ICD therapy in CRT-D versus ICD patients: A MADIT-RIT sub-study. Circulation: Arrhythmia and Electrophysiology, 9(1), [e001965]. https://doi.org/10.1161/CIRCEP.114.001965

Novel ICD programming and inappropriate ICD therapy in CRT-D versus ICD patients : A MADIT-RIT sub-study. / Kutyifa, Valentina; Daubert, James P.; Schuger, Claudio; Goldenberg, Ilan; Klein, Helmut; Aktas, Mehmet K.; McNitt, Scott; Stockburger, Martin; Merkely, B.; Zareba, Wojciech; Moss, Arthur J.

In: Circulation: Arrhythmia and Electrophysiology, Vol. 9, No. 1, e001965, 01.01.2016.

Research output: Contribution to journalArticle

Kutyifa, V, Daubert, JP, Schuger, C, Goldenberg, I, Klein, H, Aktas, MK, McNitt, S, Stockburger, M, Merkely, B, Zareba, W & Moss, AJ 2016, 'Novel ICD programming and inappropriate ICD therapy in CRT-D versus ICD patients: A MADIT-RIT sub-study', Circulation: Arrhythmia and Electrophysiology, vol. 9, no. 1, e001965. https://doi.org/10.1161/CIRCEP.114.001965
Kutyifa, Valentina ; Daubert, James P. ; Schuger, Claudio ; Goldenberg, Ilan ; Klein, Helmut ; Aktas, Mehmet K. ; McNitt, Scott ; Stockburger, Martin ; Merkely, B. ; Zareba, Wojciech ; Moss, Arthur J. / Novel ICD programming and inappropriate ICD therapy in CRT-D versus ICD patients : A MADIT-RIT sub-study. In: Circulation: Arrhythmia and Electrophysiology. 2016 ; Vol. 9, No. 1.
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