Novel Friedel-Crafts alkylation of estrogens in the presence of anhydrous FeCl3 or FeCl3-graphite as catalyst

György Göndös, György Dombi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The introduction of a tert-butyl group at position 2 of the A ring of estrogens leads to enhanced antioxidant effects. Therefore, a generally applicable and convenient method was developed using FeCl3-graphite or anhydrous FeCl3 as catalysts in the Friedel-Crafts alkylation of estrogens. The rates and yields of the alkylations were lower with FeCl3-graphite than with anhydrous FeCl3, but the regio-selectivity of the former were higher. Both catalysts proved to be more effective than typical AlCl3.

Original languageEnglish
Pages (from-to)1279-1283
Number of pages5
JournalMonatshefte fur Chemie
Volume133
Issue number10
DOIs
Publication statusPublished - Oct 16 2002

Keywords

  • Antioxidant
  • Estrogen
  • FeCl-graphite
  • Friedel-Crafts alkylation
  • Intercalation compound

ASJC Scopus subject areas

  • Chemistry(all)

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