Novel derivatization with Sanger's reagent (2,4-dinitrofluorobenzene [DNFB]) and related methodological developments for improved detection of amphetamine enantiomers by circular dichroism spectroscopy

H. Hegedus, A. Gergely, T. Veress, P. Horváth

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A new analytical procedure based on the derivatization of amphetamine with Sanger's reagent (2,4-dinitrofluorobezene) and a subsequent circular dichroism spectroscopic analysis are proposed for the determination of amphetamine enantiomers. The main advantage of the approach is the fact that the new synthetized derivative can be detected in the visible wavelength region with significantly better sensitivity than the original amphetamine. This allows a reliable determination of the optical isomers of the amphetamine without the need of separation from some of the most frequently occurring additives such as caffeine and lactose in the case of illicit drugs, or auxiliary materials in the case of legal amphetamine containing preparations.

Original languageEnglish
Pages (from-to)458-463
Number of pages6
JournalAnalusis
Volume27
Issue number5
Publication statusPublished - Jun 1999

Fingerprint

Dinitrofluorobenzene
Circular dichroism spectroscopy
Caffeine
Spectroscopic analysis
Enantiomers
Dichroism
Amphetamine
Isomers
Derivatives
Wavelength
Street Drugs
Lactose

Keywords

  • 2,4- dinitrofluorobenzene[DNFB]
  • Amphetamine
  • Circular dichroism
  • Derivatization

ASJC Scopus subject areas

  • Chemistry(all)
  • Engineering(all)

Cite this

@article{8d9120513b294fb38a2c45b26324ba1b,
title = "Novel derivatization with Sanger's reagent (2,4-dinitrofluorobenzene [DNFB]) and related methodological developments for improved detection of amphetamine enantiomers by circular dichroism spectroscopy",
abstract = "A new analytical procedure based on the derivatization of amphetamine with Sanger's reagent (2,4-dinitrofluorobezene) and a subsequent circular dichroism spectroscopic analysis are proposed for the determination of amphetamine enantiomers. The main advantage of the approach is the fact that the new synthetized derivative can be detected in the visible wavelength region with significantly better sensitivity than the original amphetamine. This allows a reliable determination of the optical isomers of the amphetamine without the need of separation from some of the most frequently occurring additives such as caffeine and lactose in the case of illicit drugs, or auxiliary materials in the case of legal amphetamine containing preparations.",
keywords = "2,4- dinitrofluorobenzene[DNFB], Amphetamine, Circular dichroism, Derivatization",
author = "H. Hegedus and A. Gergely and T. Veress and P. Horv{\'a}th",
year = "1999",
month = "6",
language = "English",
volume = "27",
pages = "458--463",
journal = "Analusis",
issn = "0365-4877",
publisher = "EDP Sciences",
number = "5",

}

TY - JOUR

T1 - Novel derivatization with Sanger's reagent (2,4-dinitrofluorobenzene [DNFB]) and related methodological developments for improved detection of amphetamine enantiomers by circular dichroism spectroscopy

AU - Hegedus, H.

AU - Gergely, A.

AU - Veress, T.

AU - Horváth, P.

PY - 1999/6

Y1 - 1999/6

N2 - A new analytical procedure based on the derivatization of amphetamine with Sanger's reagent (2,4-dinitrofluorobezene) and a subsequent circular dichroism spectroscopic analysis are proposed for the determination of amphetamine enantiomers. The main advantage of the approach is the fact that the new synthetized derivative can be detected in the visible wavelength region with significantly better sensitivity than the original amphetamine. This allows a reliable determination of the optical isomers of the amphetamine without the need of separation from some of the most frequently occurring additives such as caffeine and lactose in the case of illicit drugs, or auxiliary materials in the case of legal amphetamine containing preparations.

AB - A new analytical procedure based on the derivatization of amphetamine with Sanger's reagent (2,4-dinitrofluorobezene) and a subsequent circular dichroism spectroscopic analysis are proposed for the determination of amphetamine enantiomers. The main advantage of the approach is the fact that the new synthetized derivative can be detected in the visible wavelength region with significantly better sensitivity than the original amphetamine. This allows a reliable determination of the optical isomers of the amphetamine without the need of separation from some of the most frequently occurring additives such as caffeine and lactose in the case of illicit drugs, or auxiliary materials in the case of legal amphetamine containing preparations.

KW - 2,4- dinitrofluorobenzene[DNFB]

KW - Amphetamine

KW - Circular dichroism

KW - Derivatization

UR - http://www.scopus.com/inward/record.url?scp=0032876779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032876779&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032876779

VL - 27

SP - 458

EP - 463

JO - Analusis

JF - Analusis

SN - 0365-4877

IS - 5

ER -