Novel (-)deprenyl-derived selective inhibitors of B-type monoamine oxidase. The relation of structure to their action

Joseph Knoll, Zoltán Ecsery, Kálmán Magyar, Éva Sátory

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Abstract

A structure-activity relationship study has revealed the importance of the aromatic ring and the optimum length of the chain between the aromatic ring and the nitrogen for the selective inhibition of MAO-B. Among the (-)deprenyl derived new compounds described in this study N-methyl-N-propargyl-(2-furyl-1-methyl)-ethylammonium. HCl(U-1424) seems to be the most promising selective inhibitor of MAO-B.

Original languageEnglish
Pages (from-to)1739-1747
Number of pages9
JournalBiochemical Pharmacology
Volume27
Issue number13
DOIs
Publication statusPublished - 1978

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Selegiline
Monoamine Oxidase
Structure-Activity Relationship
Nitrogen
N-propargyl
ethylammonium

ASJC Scopus subject areas

  • Pharmacology

Cite this

Novel (-)deprenyl-derived selective inhibitors of B-type monoamine oxidase. The relation of structure to their action. / Knoll, Joseph; Ecsery, Zoltán; Magyar, Kálmán; Sátory, Éva.

In: Biochemical Pharmacology, Vol. 27, No. 13, 1978, p. 1739-1747.

Research output: Contribution to journalArticle

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