Novel classes of replication-associated transcripts discovered in viruses

Z. Boldogkői, Zsolt Balázs, Norbert Moldován, István Prazsák, Dóra Tombácz

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The role of RNA molecules in the priming of DNA replication and in providing a template for telomerase extension has been known for decades. Since then, several transcripts have been discovered, which play diverse roles in governing replication, including regulation of RNA primer formation, the recruitment of replication origin (Ori) recognition complex, and the assembly of replication fork. Recent studies on viral transcriptomes have revealed novel classes of replication-associated (ra)RNAs, which are expressed from the genomic locations in close vicinity to the Ori. Many of them overlap the Ori, whereas others are terminated close to the replication origin. These novel transcripts can be both protein-coding and non-coding RNAs. The Ori-overlapping part of the mRNAs is generally either the 5ʹ-untranslated regions (UTRs), or the 3ʹ-UTRs of the longer isoforms. Several raRNAs have been identified in various viral families using primarily third-generation long-read sequencing. Hyper-editing of these transcripts has also been described.

Original languageEnglish
Pages (from-to)166-175
Number of pages10
JournalRNA Biology
Volume16
Issue number2
DOIs
Publication statusPublished - Feb 1 2019

Fingerprint

Replication Origin
Origin Recognition Complex
RNA
Viruses
Untranslated RNA
5' Untranslated Regions
Telomerase
3' Untranslated Regions
DNA Replication
Transcriptome
Protein Isoforms
Messenger RNA
Proteins
RNA primers

Keywords

  • DNA polymerase
  • long-read sequencing
  • non-coding RNA
  • replication fork
  • replication origin
  • replication-associated transcript
  • Viruses

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Novel classes of replication-associated transcripts discovered in viruses. / Boldogkői, Z.; Balázs, Zsolt; Moldován, Norbert; Prazsák, István; Tombácz, Dóra.

In: RNA Biology, Vol. 16, No. 2, 01.02.2019, p. 166-175.

Research output: Contribution to journalReview article

Boldogkői, Z, Balázs, Z, Moldován, N, Prazsák, I & Tombácz, D 2019, 'Novel classes of replication-associated transcripts discovered in viruses', RNA Biology, vol. 16, no. 2, pp. 166-175. https://doi.org/10.1080/15476286.2018.1564468
Boldogkői, Z. ; Balázs, Zsolt ; Moldován, Norbert ; Prazsák, István ; Tombácz, Dóra. / Novel classes of replication-associated transcripts discovered in viruses. In: RNA Biology. 2019 ; Vol. 16, No. 2. pp. 166-175.
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