Novel carboxylated PEG-coating on magnetite nanoparticles designed for biomedical applications

E. Illés, E. Tombácz, M. Szekeres, Ildikó Y. Tóth, Ákos Szabó, B. Iván

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Fabrication of PEG coating on magnetite nanoparticles (MNPs) is one of the most favoured ways to ensure biocompatibility. Surface modification of magnetite by an own-prepared comb-like PEG-copolymer (PEGA-AA) was compared with two commercially available ones (carboxy-PEG (PEG-C) and phosphate-PEG (PEG-P)). ATR FT-IR data revealed that all polymers form complexes on the surface of MNPs. Electrophoresis and dynamic light scattering (DLS) experiments showed that both the type and quantity of the polymers' anchoring groups influence the aggregation of coated nanomagnets. PEG-C shell does not provide excess negative charges, so magnetite particles became aggregated. However PEG-P and PEGA-AA gradually modify the surface: neutralizing the originally positively charged MNPs below loading 0.5 mmol/g, while above it a polyanionic layer forms on nanomagnets dispersing them in salty media at pH ~6.5. The PEGA-AA comb-like copolymer is more efficient for MNPs PEGylation due to the uniform distribution of carboxylates and PEG chains along the carbon skeleton.

Original languageEnglish
Pages (from-to)132-139
Number of pages8
JournalJournal of Magnetism and Magnetic Materials
Volume380
DOIs
Publication statusPublished - Apr 15 2015

Fingerprint

Magnetite Nanoparticles
Magnetite nanoparticles
magnetite
Polyethylene glycols
coatings
Coatings
nanoparticles
Ferrosoferric Oxide
copolymers
phosphates
Magnetite
dispersing
Polymers
polymers
Phosphates
biocompatibility
electrophoresis
Copolymers
musculoskeletal system
carboxylates

Keywords

  • Biomedical application
  • Colloid stability
  • Magnetite nanoparticle
  • PEGylated nanomagnets
  • Superhydrophilic coating

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Novel carboxylated PEG-coating on magnetite nanoparticles designed for biomedical applications. / Illés, E.; Tombácz, E.; Szekeres, M.; Tóth, Ildikó Y.; Szabó, Ákos; Iván, B.

In: Journal of Magnetism and Magnetic Materials, Vol. 380, 15.04.2015, p. 132-139.

Research output: Contribution to journalArticle

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