Novel bis (crown ether)-based potassium sensor for biological applications

Ernö Lindner, Klára Tóth, Judit Jeney, Mária Horváth, Ernö Pungor, István Bitter, Béla Ágai, László Töke

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Based on structure-selectivity studies on bis-benzo-crown ether derivatives, 2,2′-bis[3,4-(15-crown-5)-2-nitrophenylcarbamoxymethyl]tetradecane (BME-44) was designed and synthesized. The performance characteristics of this new, highly lipophilic ionophore of the group of bis-nitrobenzo-15-crown-5 derivatives with urethane linkage when used in liquid membrane electrodes are evaluated with special regard to the requirements of biological and clinical applications. Potentiometric steady-state and flow-through dynamic data are presented to prove the sensor capabilities for clinical and physiological potassium determinations.

Original languageEnglish
Pages (from-to)157-168
Number of pages12
JournalMikrochimica Acta
Issue number3-4
Publication statusPublished - May 1 1990



  • bis-crown-ether
  • blood analysis
  • flow-injection analysis
  • liquid membrane
  • potassium sensor
  • urine analysis

ASJC Scopus subject areas

  • Analytical Chemistry

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