Novel biocompatible polysaccharide-based self-healing hydrogel

Zhao Wei, Jian Hai Yang, Zhen Qi Liu, Feng Xu, Jin Xiong Zhou, M. Zrínyi, Yoshihito Osada, Yong Mei Chen

Research output: Contribution to journalArticle

211 Citations (Scopus)

Abstract

A novel biocompatible polysaccharide-based self-healing hydrogel, CEC-l-OSA-l-ADH hydrogel ("l" means "linked-by"), is developed by exploiting the dynamic reaction of N-carboxyethyl chitosan (CEC) and adipic acid dihydrazide (ADH) with oxidized sodium alginate (OSA). The self-healing ability, as demonstrated by rheological recovery, macroscopic observation, and beam-shaped strain compression measurement, is attributed to the coexistence of dynamic imine and acylhydrazone bonds in the hydrogel networks. The CEC-l-OSA-l-ADH hydrogel shows excellent self-healing ability under physiological conditions with a high healing efficiency (up to 95%) without need for any external stimuli. In addition, the CEC-l-OSA-l-ADH hydrogel exhibits good cytocompatibility and cell release as demonstrated by three-dimensional cell encapsulation. With these superior properties, the developed hydrogel holds great potential for applications in various biomedical fields, e.g., as cell or drug delivery carriers.

Original languageEnglish
Pages (from-to)1352-1359
Number of pages8
JournalAdvanced Functional Materials
Volume25
Issue number9
DOIs
Publication statusPublished - Mar 4 2015

Fingerprint

polysaccharides
Hydrogel
healing
Polysaccharides
Hydrogels
Sodium alginate
sodium
Chitosan
acids
Acids
cells
stimuli
imines
delivery
drugs
Imines
recovery
Drug delivery
Encapsulation
Recovery

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Condensed Matter Physics
  • Electrochemistry

Cite this

Wei, Z., Yang, J. H., Liu, Z. Q., Xu, F., Zhou, J. X., Zrínyi, M., ... Chen, Y. M. (2015). Novel biocompatible polysaccharide-based self-healing hydrogel. Advanced Functional Materials, 25(9), 1352-1359. https://doi.org/10.1002/adfm.201401502

Novel biocompatible polysaccharide-based self-healing hydrogel. / Wei, Zhao; Yang, Jian Hai; Liu, Zhen Qi; Xu, Feng; Zhou, Jin Xiong; Zrínyi, M.; Osada, Yoshihito; Chen, Yong Mei.

In: Advanced Functional Materials, Vol. 25, No. 9, 04.03.2015, p. 1352-1359.

Research output: Contribution to journalArticle

Wei, Z, Yang, JH, Liu, ZQ, Xu, F, Zhou, JX, Zrínyi, M, Osada, Y & Chen, YM 2015, 'Novel biocompatible polysaccharide-based self-healing hydrogel', Advanced Functional Materials, vol. 25, no. 9, pp. 1352-1359. https://doi.org/10.1002/adfm.201401502
Wei, Zhao ; Yang, Jian Hai ; Liu, Zhen Qi ; Xu, Feng ; Zhou, Jin Xiong ; Zrínyi, M. ; Osada, Yoshihito ; Chen, Yong Mei. / Novel biocompatible polysaccharide-based self-healing hydrogel. In: Advanced Functional Materials. 2015 ; Vol. 25, No. 9. pp. 1352-1359.
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