Novel bioceramics for bone implants

P. I. Gouma, K. Ramachandran, M. Firat, M. Connolly, R. Zuckermann, Cs Balaszi, P. L. Perrotta, R. Xue

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Electrospun cellulose acetate (eCA) and its hybrid with nanoaggregates of hydroxyapatite (eCA-nHA) were developed as potential and novel materials for bone tissue engineering purposes. Cultured human osteoblasts were seeded on eCA and eCA-nHA scaffolds, after which cell proliferative capacity and viability were studied using complementary assays. The interactions between the cells and the scaffolds were further characterized by scanning electron microscopy (SEM). These studies demonstrated that the scaffolds supported cell growth, as evidenced by continued cell proliferation for up to 3 days of exposure. Moreover, the osteoblasts remained viable and metabolically active while exposed to the scaffolds. SEM images detailed the tight interactions between the cell membranes and electrospun fibers. The presence of the hydroxyapatite nanoaggregates appeared to enhance osteoblast attachment, while allowing the cells to spread out along the fibers. These studies show that both eCA fiber and eCA-nHA fibrous nanoeomposite scaffolds hold promise for bone tissue engineering applications.

Original languageEnglish
Title of host publicationAdvances in Bioceramics and Porous Ceramics II - A Collection of Papers Presented at the 33rd International Conference on Advanced Ceramics and Composites
Pages35-44
Number of pages10
Edition6
Publication statusPublished - May 13 2010
EventAdvances in Bioceramics and Porous Ceramics II - 33rd International Conference on Advanced Ceramics and Composites - Daytona Beach, FL, United States
Duration: Jan 18 2009Jan 23 2009

Publication series

NameCeramic Engineering and Science Proceedings
Number6
Volume30
ISSN (Print)0196-6219

Other

OtherAdvances in Bioceramics and Porous Ceramics II - 33rd International Conference on Advanced Ceramics and Composites
CountryUnited States
CityDaytona Beach, FL
Period1/18/091/23/09

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ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

Cite this

Gouma, P. I., Ramachandran, K., Firat, M., Connolly, M., Zuckermann, R., Balaszi, C., Perrotta, P. L., & Xue, R. (2010). Novel bioceramics for bone implants. In Advances in Bioceramics and Porous Ceramics II - A Collection of Papers Presented at the 33rd International Conference on Advanced Ceramics and Composites (6 ed., pp. 35-44). (Ceramic Engineering and Science Proceedings; Vol. 30, No. 6).