Novel bioceramics for bone implants

P. I. Gouma, K. Ramachandran, M. Firat, M. Connolly, R. Zuckermann, C. Balázsi, P. L. Perrotta, R. Xue

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Electrospun cellulose acetate (eCA) and its hybrid with nanoaggregates of hydroxyapatite (eCA-nHA) were developed as potential and novel materials for bone tissue engineering purposes. Cultured human osteoblasts were seeded on eCA and eCA-nHA scaffolds, after which cell proliferative capacity and viability were studied using complementary assays. The interactions between the cells and the scaffolds were further characterized by scanning electron microscopy (SEM). These studies demonstrated that the scaffolds supported cell growth, as evidenced by continued cell proliferation for up to 3 days of exposure. Moreover, the osteoblasts remained viable and metabolically active while exposed to the scaffolds. SEM images detailed the tight interactions between the cell membranes and electrospun fibers. The presence of the hydroxyapatite nanoaggregates appeared to enhance osteoblast attachment, while allowing the cells to spread out along the fibers. These studies show that both eCA fiber and eCA-nHA fibrous nanoeomposite scaffolds hold promise for bone tissue engineering applications.

Original languageEnglish
Title of host publicationCeramic Engineering and Science Proceedings
Pages35-44
Number of pages10
Volume30
Edition6
Publication statusPublished - 2010
EventAdvances in Bioceramics and Porous Ceramics II - 33rd International Conference on Advanced Ceramics and Composites - Daytona Beach, FL, United States
Duration: Jan 18 2009Jan 23 2009

Other

OtherAdvances in Bioceramics and Porous Ceramics II - 33rd International Conference on Advanced Ceramics and Composites
CountryUnited States
CityDaytona Beach, FL
Period1/18/091/23/09

Fingerprint

Bioceramics
Cellulose
Bone
Osteoblasts
Scaffolds
Durapatite
Scaffolds (biology)
Hydroxyapatite
Tissue engineering
Fibers
Scanning electron microscopy
Bioelectric potentials
Cell proliferation
Cell growth
Cell membranes
acetylcellulose
Assays

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

Cite this

Gouma, P. I., Ramachandran, K., Firat, M., Connolly, M., Zuckermann, R., Balázsi, C., ... Xue, R. (2010). Novel bioceramics for bone implants. In Ceramic Engineering and Science Proceedings (6 ed., Vol. 30, pp. 35-44)

Novel bioceramics for bone implants. / Gouma, P. I.; Ramachandran, K.; Firat, M.; Connolly, M.; Zuckermann, R.; Balázsi, C.; Perrotta, P. L.; Xue, R.

Ceramic Engineering and Science Proceedings. Vol. 30 6. ed. 2010. p. 35-44.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gouma, PI, Ramachandran, K, Firat, M, Connolly, M, Zuckermann, R, Balázsi, C, Perrotta, PL & Xue, R 2010, Novel bioceramics for bone implants. in Ceramic Engineering and Science Proceedings. 6 edn, vol. 30, pp. 35-44, Advances in Bioceramics and Porous Ceramics II - 33rd International Conference on Advanced Ceramics and Composites, Daytona Beach, FL, United States, 1/18/09.
Gouma PI, Ramachandran K, Firat M, Connolly M, Zuckermann R, Balázsi C et al. Novel bioceramics for bone implants. In Ceramic Engineering and Science Proceedings. 6 ed. Vol. 30. 2010. p. 35-44
Gouma, P. I. ; Ramachandran, K. ; Firat, M. ; Connolly, M. ; Zuckermann, R. ; Balázsi, C. ; Perrotta, P. L. ; Xue, R. / Novel bioceramics for bone implants. Ceramic Engineering and Science Proceedings. Vol. 30 6. ed. 2010. pp. 35-44
@inproceedings{4477500c4df84c00bd66a61285e4702b,
title = "Novel bioceramics for bone implants",
abstract = "Electrospun cellulose acetate (eCA) and its hybrid with nanoaggregates of hydroxyapatite (eCA-nHA) were developed as potential and novel materials for bone tissue engineering purposes. Cultured human osteoblasts were seeded on eCA and eCA-nHA scaffolds, after which cell proliferative capacity and viability were studied using complementary assays. The interactions between the cells and the scaffolds were further characterized by scanning electron microscopy (SEM). These studies demonstrated that the scaffolds supported cell growth, as evidenced by continued cell proliferation for up to 3 days of exposure. Moreover, the osteoblasts remained viable and metabolically active while exposed to the scaffolds. SEM images detailed the tight interactions between the cell membranes and electrospun fibers. The presence of the hydroxyapatite nanoaggregates appeared to enhance osteoblast attachment, while allowing the cells to spread out along the fibers. These studies show that both eCA fiber and eCA-nHA fibrous nanoeomposite scaffolds hold promise for bone tissue engineering applications.",
author = "Gouma, {P. I.} and K. Ramachandran and M. Firat and M. Connolly and R. Zuckermann and C. Bal{\'a}zsi and Perrotta, {P. L.} and R. Xue",
year = "2010",
language = "English",
isbn = "9780470457566",
volume = "30",
pages = "35--44",
booktitle = "Ceramic Engineering and Science Proceedings",
edition = "6",

}

TY - GEN

T1 - Novel bioceramics for bone implants

AU - Gouma, P. I.

AU - Ramachandran, K.

AU - Firat, M.

AU - Connolly, M.

AU - Zuckermann, R.

AU - Balázsi, C.

AU - Perrotta, P. L.

AU - Xue, R.

PY - 2010

Y1 - 2010

N2 - Electrospun cellulose acetate (eCA) and its hybrid with nanoaggregates of hydroxyapatite (eCA-nHA) were developed as potential and novel materials for bone tissue engineering purposes. Cultured human osteoblasts were seeded on eCA and eCA-nHA scaffolds, after which cell proliferative capacity and viability were studied using complementary assays. The interactions between the cells and the scaffolds were further characterized by scanning electron microscopy (SEM). These studies demonstrated that the scaffolds supported cell growth, as evidenced by continued cell proliferation for up to 3 days of exposure. Moreover, the osteoblasts remained viable and metabolically active while exposed to the scaffolds. SEM images detailed the tight interactions between the cell membranes and electrospun fibers. The presence of the hydroxyapatite nanoaggregates appeared to enhance osteoblast attachment, while allowing the cells to spread out along the fibers. These studies show that both eCA fiber and eCA-nHA fibrous nanoeomposite scaffolds hold promise for bone tissue engineering applications.

AB - Electrospun cellulose acetate (eCA) and its hybrid with nanoaggregates of hydroxyapatite (eCA-nHA) were developed as potential and novel materials for bone tissue engineering purposes. Cultured human osteoblasts were seeded on eCA and eCA-nHA scaffolds, after which cell proliferative capacity and viability were studied using complementary assays. The interactions between the cells and the scaffolds were further characterized by scanning electron microscopy (SEM). These studies demonstrated that the scaffolds supported cell growth, as evidenced by continued cell proliferation for up to 3 days of exposure. Moreover, the osteoblasts remained viable and metabolically active while exposed to the scaffolds. SEM images detailed the tight interactions between the cell membranes and electrospun fibers. The presence of the hydroxyapatite nanoaggregates appeared to enhance osteoblast attachment, while allowing the cells to spread out along the fibers. These studies show that both eCA fiber and eCA-nHA fibrous nanoeomposite scaffolds hold promise for bone tissue engineering applications.

UR - http://www.scopus.com/inward/record.url?scp=77951979539&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951979539&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:77951979539

SN - 9780470457566

VL - 30

SP - 35

EP - 44

BT - Ceramic Engineering and Science Proceedings

ER -