Novel bioactive glass-AuNP composites for biomedical applications

K. Magyari, T. Nagy-Simon, A. Vulpoi, R. A. Popescu, E. Licarete, R. Stefan, K. Hernádi, I. Papuc, L. Baia

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The bioactive glasses doped with gold nanoparticles (AuNPs) are very attractive materials due to their potential in medical applications. In the present study Pluronic-nanogold hybrid nanoparticles were introduced during the sol-gel route of the SiO2-CaO-P2O5 glasses preparation. The obtained samples were characterized by UV–vis spectroscopy, X-ray diffraction, FT-IR spectroscopy, transmission electron and scanning electron microscopy and afterwards they were investigated in terms of bioactivity, protein adsorption and cells viability. The in vitro bioactivity assessment shows the increase of the number of agglomerated spherical shapes of apatite layers for all Au containing samples, but apatite like structure sizes are influenced by the AuNP content. Beside the spherical shapes, three-dimensional flower-like nanostructures were observed on the surface of the glass with 0.2 mol% Au2O. Zeta potential and fluorescence spectroscopy measurements evidenced that the amount of serum albumin adsorbed onto the composites surface increases with the AuNP content. FT-IR measurements point out that the secondary structure of the adsorbed proteins presents few minor changes, indicating biocompatibility of the AuNP doped glasses. The good proliferation rate of Human keratinocytes cells obtained in the presence of samples with 0.15 and 0.2 mol% Au2O is comparable with the values achieved from free AuNP, fact that proves the preservation of AuNP properties after their incorporation inside the bioactive glass matrices.

Original languageEnglish
Pages (from-to)752-759
Number of pages8
JournalMaterials Science and Engineering C
Volume76
DOIs
Publication statusPublished - Jul 1 2017

Keywords

  • Bioactive glasses
  • Cell viability
  • Gold nanoparticles
  • Protein adsorption

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Magyari, K., Nagy-Simon, T., Vulpoi, A., Popescu, R. A., Licarete, E., Stefan, R., Hernádi, K., Papuc, I., & Baia, L. (2017). Novel bioactive glass-AuNP composites for biomedical applications. Materials Science and Engineering C, 76, 752-759. https://doi.org/10.1016/j.msec.2017.03.138