Novel approaches for the study of vascular assembly and morphogenesis in avian embryos

Paul A. Rupp, András Czirók, Charles D. Little

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Dynamic imaging of primary capillary bed formation in a warm-blooded embryo now is readily accomplished with the use of modern digital cameras, software, and instrumentation. The precise dynamic behavior of endothelial cells and their emergent vascular patterns are easily recorded and quantified in exquisite detail. As an example, we present data regarding vasculogenesis and vascular remodeling under normal and vascular endothelial growth factor-stimulated conditions, including corresponding computational analyses of endothelial cell behavior. The results show that the quail embryo provides an excellent experimental system to test reagents hypothesized to play a role in vascularization of tumors, engineered tissues, or wound sites.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalTrends in Cardiovascular Medicine
Volume13
Issue number7
DOIs
Publication statusPublished - Oct 1 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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