Recently, it has been shown that excess noises generated or modified by chemical agents can be used to detect and identify chemicals with enhanced sensitivity and selectivity. Moreover thermal noise and its artificial versions (Johnson-like noises) can be utilized as information carriers with peculiar properties. The first application is called Fluctuation-Enhanced Sensing. The second class can be called Thermal Noise Informatics with relevant topics are Zero Power Classical Communication and (in the quantum limit) Zero-Quantum Quantum Communication; Thermal Noise Driven Computing; and Totally Secure Classical Communication. In the paper version of this talk, we will briefly describe the scope of these fields and in the oral talk we also provide extended considerations and results.