Novel antioxidants in anthracycline cardiotoxicity

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17 Citations (Scopus)

Abstract

It has been suggested nitroxides and their amine precursors prevent incidence of damage caused by superoxide and hydroxyl radicals formed during the oxidative metabolism of doxorubicin (DOX) and daunorubicin (DAU). Both doxorubicin and daunorubicin have been associated with cardiac toxicity in both adults and children. The authors herein suggest that cardioprotective molecules modified by nitroxides and their secondary amine precursors can prevent or diminish the anthracycline-induced cardiomyopathy by accumulating in cardiomiocytes.

Original languageEnglish
Pages (from-to)160-164
Number of pages5
JournalCardiovascular Toxicology
Volume7
Issue number2
DOIs
Publication statusPublished - Jun 1 2007

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Keywords

  • Anthracyclines
  • Antioxidants
  • Cardiomyopathy
  • EPR
  • Free radicals
  • Nitroxides

ASJC Scopus subject areas

  • Molecular Biology
  • Toxicology
  • Cardiology and Cardiovascular Medicine

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