Novel and Neuroprotective Tetranortriterpenoids from Chinese Mangrove Xylocarpus granatum Koenig

Zhen Fang Zhou, T. Kurtán, Attila Mándi, Yu Cheng Gu, Li Gong Yao, Guo Rong Xin, Xu Wen Li, Yue Wei Guo

Research output: Contribution to journalArticle

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Abstract

Eight new tetranortriterpenoids (1-8) were isolated from the twigs and leaves of the Chinese mangrove plant Xylocarpus granatum, together with four related known ones (9-12). The structures of new compounds were elucidated by detailed spectroscopic analysis. The absolute configuration of 9-epixylogranatin A (1) was determined by time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations of the solution conformers. Xylogranatumin A (2) represents the first example of the 9, 10-seco limonoid with an unprecedented oxygen-bridged B ring (2,7-dioxabicyclo[2.2.1]-heptane). All the isolates were evaluated for the in vitro neuroprotective activity, both compounds 11 and 12 displayed moderate effects against H 2 O 2 -induced neurotoxicity in PC12 cells at the concentration of 10 μM, with an increase in cell viability of 12.0% and 11.6%, respectively.

Original languageEnglish
Article number33908
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - Sep 23 2016

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Limonins
Heptanes
Spectroscopic analysis
Dichroism
Density functional theory
Cells
Oxygen

ASJC Scopus subject areas

  • General

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Novel and Neuroprotective Tetranortriterpenoids from Chinese Mangrove Xylocarpus granatum Koenig. / Zhou, Zhen Fang; Kurtán, T.; Mándi, Attila; Gu, Yu Cheng; Yao, Li Gong; Xin, Guo Rong; Li, Xu Wen; Guo, Yue Wei.

In: Scientific Reports, Vol. 6, 33908, 23.09.2016.

Research output: Contribution to journalArticle

Zhou, Zhen Fang ; Kurtán, T. ; Mándi, Attila ; Gu, Yu Cheng ; Yao, Li Gong ; Xin, Guo Rong ; Li, Xu Wen ; Guo, Yue Wei. / Novel and Neuroprotective Tetranortriterpenoids from Chinese Mangrove Xylocarpus granatum Koenig. In: Scientific Reports. 2016 ; Vol. 6.
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