Novel amino acid-based polymers for pharmaceutical applications

V. Torma, Tamás Gyenes, Zoltán Szakács, B. Noszál, Árpád Némethy, M. Zrínyi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Entirely amino acid-based polymers were prepared by side-chain attachment to polysuccinimide derived from the thermal polycondensation of aspartic acid. Following deprotonation of various amino acid ester hydrochlorides by a secondary amine, the restored primary amino groups initiated the ring-opening of succinimide to form amide bonds. 1H and 13C NMR measurements revealed that the mole fraction of the introduced amino acid side chains could be controlled by the reaction time, while no hydrolysis of methyl ester groups was observed. The synthesized polymers contain exclusively amino acids, which makes them promising candidates as base materials of controlled drug delivery systems.

Original languageEnglish
Pages (from-to)311-318
Number of pages8
JournalPolymer Bulletin
Volume59
Issue number3
DOIs
Publication statusPublished - Oct 2007

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Drug products
amino acids
Amino acids
Polymers
Amino Acids
polymers
Pharmaceutical Preparations
esters
Esters
succinimides
Controlled drug delivery
aspartic acid
Deprotonation
hydrochlorides
Polycondensation
Amides
Aspartic Acid
reaction time
amides
Amines

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry

Cite this

Novel amino acid-based polymers for pharmaceutical applications. / Torma, V.; Gyenes, Tamás; Szakács, Zoltán; Noszál, B.; Némethy, Árpád; Zrínyi, M.

In: Polymer Bulletin, Vol. 59, No. 3, 10.2007, p. 311-318.

Research output: Contribution to journalArticle

Torma, V. ; Gyenes, Tamás ; Szakács, Zoltán ; Noszál, B. ; Némethy, Árpád ; Zrínyi, M. / Novel amino acid-based polymers for pharmaceutical applications. In: Polymer Bulletin. 2007 ; Vol. 59, No. 3. pp. 311-318.
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