Novel amino acid-based polymers for pharmaceutical applications

Viktória Torma, Tamás Gyenes, Zoltán Szakács, Béla Noszál, Árpád Némethy, Miklós Zrínyi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Entirely amino acid-based polymers were prepared by side-chain attachment to polysuccinimide derived from the thermal polycondensation of aspartic acid. Following deprotonation of various amino acid ester hydrochlorides by a secondary amine, the restored primary amino groups initiated the ring-opening of succinimide to form amide bonds. 1H and 13C NMR measurements revealed that the mole fraction of the introduced amino acid side chains could be controlled by the reaction time, while no hydrolysis of methyl ester groups was observed. The synthesized polymers contain exclusively amino acids, which makes them promising candidates as base materials of controlled drug delivery systems.

Original languageEnglish
Pages (from-to)311-318
Number of pages8
JournalPolymer Bulletin
Volume59
Issue number3
DOIs
Publication statusPublished - Oct 1 2007

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Polymers and Plastics
  • Materials Chemistry

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