A Notch-jeltovábbító rendszer szerepe a vérképzés szabályozásában

Translated title of the contribution: Notch signaling in the regulation of hematopoiesis

Virág Vas, Zsuzsanna Kertész, Katalin Pálóczi, Ferenc Uher

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Notch signaling defines an evolutionary ancient cell interaction mechanism. The signals transmitted through the Notch receptor, in combination with other cellular factors influence differentiation, proliferation and apoptotic events at all stages of development. Recent advances have elucidated both the biochemical mechanism regulating receptor activation and the molecular participants forming the intracellular signaling cascade. Authors present description of the main signaling components involved in the Notch pathway and how it can affect the growth and function of lymphocytes. Notch signaling is critical during lymphocyte development, and dysregulation of the pathway can give rise to leukemia. It is conceivable that appropriate manipulation of Notch signaling may become a useful tool in addressing a variety of human dysplastic condition and tissue regeneration.

Translated title of the contributionNotch signaling in the regulation of hematopoiesis
Original languageHungarian
Pages (from-to)309-316
Number of pages8
JournalOrvosi hetilap
Volume146
Issue number7
Publication statusPublished - Dec 1 2005

ASJC Scopus subject areas

  • Medicine(all)

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