NOS-positive local circuit neurons are exclusively axo-dendritic cells both in the neo- and archicortex of the rat brain

L. Séress, H. Ábrahám, András Hajnal, Hong Lin, Susan Totterdell

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Neuronal nitric oxide synthase (nNOS)-containing neurons and axon terminals were examined in the rat somatosensory and temporal neocortex, in the CA3/a-c areas of Ammon's horn and in the hippocampal dentate gyrus. In these areas, only nonpyramidal neurons were labeled with the antibody against nNOS. Previous observations suggested that all nNOS-positive nonpyramidal cells are GABAergic local circuit neurons, which form exclusively symmetric synapses. In agreement with this, nNOS-positive axon terminals in the hippocampal formation formed symmetric synapses exclusively with dendritic shafts. In the neocortex, in contrast, in addition to the nNOS-positive axon terminals that formed synapses with unlabeled spiny and aspiny dendrites and with nNOS-positive aspiny dendrites, a small proportion of the nNOS-positive axon terminals formed symmetric synapses with dendritic spines. These results suggest that nNOS-positive local circuit neurons form a distinct group of axo-dendritic cells displaying slightly different domain specificity in the archi- and neocortex. However, nNOS-positive cells show no target selectivity, because they innervate principal cells and local circuit neurons. Afferents to the NOS-positive cells display neither domain nor target selectivity, because small unlabeled terminals formed synapses with both the soma or dendrites of nNOS-positive neurons and an adjacent unlabeled dendrite or spine in both the hippocampal formation and in neocortex.

Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalBrain Research
Volume1056
Issue number2
DOIs
Publication statusPublished - Sep 21 2005

Fingerprint

Nitric Oxide Synthase Type I
Neocortex
Dendritic Cells
Neurons
Brain
Synapses
Presynaptic Terminals
Dendrites
Hippocampus
Parahippocampal Gyrus
Dendritic Spines
Dentate Gyrus
Carisoprodol
Spine

Keywords

  • Ammon's horn
  • Dentate gyrus
  • Inhibitory neuron
  • Somatosensory cortex
  • Temporal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

NOS-positive local circuit neurons are exclusively axo-dendritic cells both in the neo- and archicortex of the rat brain. / Séress, L.; Ábrahám, H.; Hajnal, András; Lin, Hong; Totterdell, Susan.

In: Brain Research, Vol. 1056, No. 2, 21.09.2005, p. 183-190.

Research output: Contribution to journalArticle

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