Normal stimulation of the synthesis, phosphorylation and DNA binding activity of c-Fos and Zif268 proteins by nerve growth factor is not sufficient to mediate neuronal differentiation of PC12 cells

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Abstract

Early-response genes (ERGs) are rapidly induced by nerve growth factor (NGF) in the PC12 rat pheochromocytoma cell line. To analyze the possible role of Ras and ERGs in neuronal differentiation, experiments were carried out to study the involvement of Ras proteins in the NGF-stimulated expression of two ERG-coded proteins (c-Fos and Zif268) implicated in NGF signaling. Using PC12 subclones expressing the dominant negative Ha-Ras Asn-17 protein, NGF-induced expression, phosphorylation and DNA-binding of these ERG products were found to be not sufficient to convey the biological response of PC12 cells to NGF.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalMolecular and Cellular Biochemistry
Volume189
Issue number1-2
DOIs
Publication statusPublished - 1998

Keywords

  • Nerve growth factor
  • Neuronal differentiation
  • PC12 cells
  • Zif268
  • c-Fos

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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