Normal and abnormal transformation of the spiral arteries during pregnancy

Jimmy Espinoza, Roberto Romero, Mee Kim Yeon, Juan Pedro Kusanovic, Sonia Hassan, Offer Erez, Francesca Gotsch, Nandor Gabor Than, Z. Papp, Jai Kim Chong

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

This article reviews the anatomy and physiology of the uterine circulation, with emphasis on the remodeling of spiral arteries during normal pregnancy, and the timing and anatomical pathways of trophoblast invasion of the spiral arteries. We review the definitions of the placental bed and basal plate of the placenta, their relevance to the study of the physiologic transformation of the spiral arteries, as well as the methods to obtain and examine placental bed biopsy specimens. We also examine the role of the extravillous trophoblast in normal and abnormal pregnancies, and the criteria used to diagnose failure of physiologic transformation of the spiral arteries. Finally, we comment on the use of uterine artery Doppler velocimetry as a surrogate marker of chronic uteroplacental ischemia.

Original languageEnglish
Pages (from-to)447-458
Number of pages12
JournalJournal of Perinatal Medicine
Volume34
Issue number6
DOIs
Publication statusPublished - Dec 1 2006

Fingerprint

Arteries
Pregnancy
Trophoblasts
Uterine Artery
Rheology
Placenta
Anatomy
Ischemia
Biomarkers
Biopsy

Keywords

  • Atherosis
  • Immunohistochemistry
  • Impedance to blood flow
  • Integrin
  • Physiologic transformation of the spiral arteries
  • Placental bed

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Espinoza, J., Romero, R., Yeon, M. K., Kusanovic, J. P., Hassan, S., Erez, O., ... Chong, J. K. (2006). Normal and abnormal transformation of the spiral arteries during pregnancy. Journal of Perinatal Medicine, 34(6), 447-458. https://doi.org/10.1515/JPM.2006.089

Normal and abnormal transformation of the spiral arteries during pregnancy. / Espinoza, Jimmy; Romero, Roberto; Yeon, Mee Kim; Kusanovic, Juan Pedro; Hassan, Sonia; Erez, Offer; Gotsch, Francesca; Than, Nandor Gabor; Papp, Z.; Chong, Jai Kim.

In: Journal of Perinatal Medicine, Vol. 34, No. 6, 01.12.2006, p. 447-458.

Research output: Contribution to journalArticle

Espinoza, J, Romero, R, Yeon, MK, Kusanovic, JP, Hassan, S, Erez, O, Gotsch, F, Than, NG, Papp, Z & Chong, JK 2006, 'Normal and abnormal transformation of the spiral arteries during pregnancy', Journal of Perinatal Medicine, vol. 34, no. 6, pp. 447-458. https://doi.org/10.1515/JPM.2006.089
Espinoza J, Romero R, Yeon MK, Kusanovic JP, Hassan S, Erez O et al. Normal and abnormal transformation of the spiral arteries during pregnancy. Journal of Perinatal Medicine. 2006 Dec 1;34(6):447-458. https://doi.org/10.1515/JPM.2006.089
Espinoza, Jimmy ; Romero, Roberto ; Yeon, Mee Kim ; Kusanovic, Juan Pedro ; Hassan, Sonia ; Erez, Offer ; Gotsch, Francesca ; Than, Nandor Gabor ; Papp, Z. ; Chong, Jai Kim. / Normal and abnormal transformation of the spiral arteries during pregnancy. In: Journal of Perinatal Medicine. 2006 ; Vol. 34, No. 6. pp. 447-458.
@article{f8f1f68f7d8d43209036ddc2e5972602,
title = "Normal and abnormal transformation of the spiral arteries during pregnancy",
abstract = "This article reviews the anatomy and physiology of the uterine circulation, with emphasis on the remodeling of spiral arteries during normal pregnancy, and the timing and anatomical pathways of trophoblast invasion of the spiral arteries. We review the definitions of the placental bed and basal plate of the placenta, their relevance to the study of the physiologic transformation of the spiral arteries, as well as the methods to obtain and examine placental bed biopsy specimens. We also examine the role of the extravillous trophoblast in normal and abnormal pregnancies, and the criteria used to diagnose failure of physiologic transformation of the spiral arteries. Finally, we comment on the use of uterine artery Doppler velocimetry as a surrogate marker of chronic uteroplacental ischemia.",
keywords = "Atherosis, Immunohistochemistry, Impedance to blood flow, Integrin, Physiologic transformation of the spiral arteries, Placental bed",
author = "Jimmy Espinoza and Roberto Romero and Yeon, {Mee Kim} and Kusanovic, {Juan Pedro} and Sonia Hassan and Offer Erez and Francesca Gotsch and Than, {Nandor Gabor} and Z. Papp and Chong, {Jai Kim}",
year = "2006",
month = "12",
day = "1",
doi = "10.1515/JPM.2006.089",
language = "English",
volume = "34",
pages = "447--458",
journal = "Journal of Perinatal Medicine",
issn = "0300-5577",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "6",

}

TY - JOUR

T1 - Normal and abnormal transformation of the spiral arteries during pregnancy

AU - Espinoza, Jimmy

AU - Romero, Roberto

AU - Yeon, Mee Kim

AU - Kusanovic, Juan Pedro

AU - Hassan, Sonia

AU - Erez, Offer

AU - Gotsch, Francesca

AU - Than, Nandor Gabor

AU - Papp, Z.

AU - Chong, Jai Kim

PY - 2006/12/1

Y1 - 2006/12/1

N2 - This article reviews the anatomy and physiology of the uterine circulation, with emphasis on the remodeling of spiral arteries during normal pregnancy, and the timing and anatomical pathways of trophoblast invasion of the spiral arteries. We review the definitions of the placental bed and basal plate of the placenta, their relevance to the study of the physiologic transformation of the spiral arteries, as well as the methods to obtain and examine placental bed biopsy specimens. We also examine the role of the extravillous trophoblast in normal and abnormal pregnancies, and the criteria used to diagnose failure of physiologic transformation of the spiral arteries. Finally, we comment on the use of uterine artery Doppler velocimetry as a surrogate marker of chronic uteroplacental ischemia.

AB - This article reviews the anatomy and physiology of the uterine circulation, with emphasis on the remodeling of spiral arteries during normal pregnancy, and the timing and anatomical pathways of trophoblast invasion of the spiral arteries. We review the definitions of the placental bed and basal plate of the placenta, their relevance to the study of the physiologic transformation of the spiral arteries, as well as the methods to obtain and examine placental bed biopsy specimens. We also examine the role of the extravillous trophoblast in normal and abnormal pregnancies, and the criteria used to diagnose failure of physiologic transformation of the spiral arteries. Finally, we comment on the use of uterine artery Doppler velocimetry as a surrogate marker of chronic uteroplacental ischemia.

KW - Atherosis

KW - Immunohistochemistry

KW - Impedance to blood flow

KW - Integrin

KW - Physiologic transformation of the spiral arteries

KW - Placental bed

UR - http://www.scopus.com/inward/record.url?scp=33845290257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845290257&partnerID=8YFLogxK

U2 - 10.1515/JPM.2006.089

DO - 10.1515/JPM.2006.089

M3 - Article

C2 - 17140293

AN - SCOPUS:33845290257

VL - 34

SP - 447

EP - 458

JO - Journal of Perinatal Medicine

JF - Journal of Perinatal Medicine

SN - 0300-5577

IS - 6

ER -