Noradrenaline releasing effect of an ouabain-like compound on pulmonary artery

E. S. Vizi, F. Oberfrank, S. Bernath, D. Lichtstein

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Abstract

The effect of ouabain and an endogenous ouabain-like compound (OLC) was studied on (3H)noradrenaline ((3H)NA) release from rabbit pulmonary artery. Similarly to ouabain, OLC enhanced the release of (3H)NA in response to electrical stimulation. These findings are the first evidence that OLC is able to act presynaptically and enhance the amount of (3H)NA release per impulse. It is suggested that this mechanism might be involved in the physiological regulation of blood pressure or in the genesis of hypertension.

Original languageEnglish
Pages (from-to)1541-1544
Number of pages4
JournalNeuropharmacology
Volume26
Issue number10
DOIs
Publication statusPublished - Oct 1987

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Keywords

  • NaK-ATPase
  • hypertension
  • noradrenaline release
  • ouabain-like compound
  • presynaptic modulation

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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