The effect of ouabain and an endogenous ouabain-like compound (OLC) was studied on (3H)noradrenaline ((3H)NA) release from rabbit pulmonary artery. Similarly to ouabain, OLC enhanced the release of (3H)NA in response to electrical stimulation. These findings are the first evidence that OLC is able to act presynaptically and enhance the amount of (3H)NA release per impulse. It is suggested that this mechanism might be involved in the physiological regulation of blood pressure or in the genesis of hypertension.
- noradrenaline release
- ouabain-like compound
- presynaptic modulation
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience